ArticleProceedings of the National Academy of Sciences of the United States of America2000
Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Dead-Space Microdomains as Explicit Barriers to Extracellular Drug Transport in Alzheimer's Disease.Pharmaceutical research · 2026Article
- Serotonergic Signaling Rewired: A Lipid Raft-Controlled Model of Synaptic Transmission Grounded in the Fundamental Parameters of Biological Systems.Life (Basel, Switzerland) · 2026Article
- A Self-Similarity Logic May Shape the Organization of the Nervous System.Advances in neurobiology · 2024Article
- Deep learning for diffusion in porous media.Scientific reports · 2023Article
- Article
- A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology.International journal of molecular sciences · 2022Review
- Engineered cell culture microenvironments for mechanobiology studies of brain neural cells.Frontiers in bioengineering and biotechnology · 2022Review
- Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in mouse brain.NMR in biomedicine · 2021Article
- Reduction of Dimensionality in Monte Carlo Simulation of Diffusion in Extracellular Space Surrounding Cubic Cells.Neurochemical research · 2020Article
- Brain lateralization probed by water diffusion at the atomic to micrometric scale.Scientific reports · 2019Article
- Anomalous water dynamics in brain: a combined diffusion magnetic resonance imaging and neutron scattering investigation.Journal of the Royal Society, Interface · 2019Article
- The need for mathematical modelling of spatial drug distribution within the brain.Fluids and barriers of the CNS · 2019Review
- Investigating epithelial-to-mesenchymal transition with integrated computational and experimental approaches.Physical biology · 2019Review
- Confocal micrographs: automated segmentation and quantitative shape analysis of neuronal cells treated with ostreolysin A/pleurotolysin B pore-forming complex.Histochemistry and cell biology · 2018Article
- Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue.Computers in biology and medicine · 2018Article
- Strategies to enhance the distribution of nanotherapeutics in the brain.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica.Scientific reports · 2017Article
- A 3D model-based simulation of demyelination to understand its effects on diffusion tensor imaging.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2017Article
- Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia.PLoS biology · 2017Article
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2 authors.
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Abstract
Diffusion of molecules in brain extracellular space is constrained by two macroscopic parameters, tortuosity factor lambda and volume fraction alpha. Recent studies in brain slices show that when osmolarity is reduced, lambda increases while alpha decreases. In contrast, with increased osmolarity, alpha increases, but lambda attains a plateau. Using homogenization theory and a variety of lattice models, we found that the plateau behavior of lambda can be explained if the shape of brain cells changes nonuniformly during the shrinking or swelling induced by osmotic challenge. The nonuniform cellular shrinkage creates residual extracellular space that temporarily traps diffusing molecules, thus impeding the macroscopic diffusion. The paper also discusses the definition of tortuosity and its independence of the measurement frame of reference.
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