ArticleProceedings of the National Academy of Sciences of the United States of America2000
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Targeting erythroid cell-derived asparagine inhibits alloimmunization in sickle cell disease.Blood advances · 2026Article
- Antiepileptic Therapy ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Anesthesia can alter the levels of corticosterone and the phosphorylation of signaling molecules.BMC research notes · 2021Article
- Differential Impact of Severity and Duration ofFrontiers in cellular neuroscience · 2021Article
- Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.Neurobiology of disease · 2018Article
- Increased NRG1-ErbB4 signaling in human symptomatic epilepsy.Scientific reports · 2017Article
- Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Persistent ictal-like activity in rat entorhinal/perirhinal cortex following washout of 4-aminopyridine.Epilepsy research · 2011Article
- Consistency and diversity of spike dynamics in the neurons of bed nucleus of stria terminalis of the rat: a dynamic clamp study.PloS one · 2010Article
- Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Involvement of the cAMP-dependent pathway in the reduction of epileptiform bursting caused by somatostatin in the mouse hippocampus.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531.American journal of physiology. Cell physiology · 2008Article
- AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling.Journal of neurochemistry · 2005Article
- Regulation of translation by ribosome shunting through phosphotyrosine-dependent coupling of adenovirus protein 100k to viral mRNAs.Journal of virology · 2005Article
- Src in synaptic transmission and plasticity.Oncogene · 2004Review
- Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Members of the Src family of nonreceptor protein tyrosine kinases (PTKs) have been implicated in the regulation of cellular excitability and synaptic plasticity. We have investigated the role of these PTKs in in vitro models of epileptiform activity. Spontaneous epileptiform discharges were induced in vitro in the CA3 region of rat hippocampal slices by superfusion with the potassium channel blocker 4-aminopyridine in Mg(2+)-free medium. In hippocampal slices treated in this fashion, Src kinase activity was increased and the frequency of epileptiform discharges could be greatly reduced by inhibitor of the Src family of PTKs, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2), but not by the inactive structural analog 4-amino-7-phenylpyrazol[3,4-d]pyrimidine (PP3). 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine also reduced epileptiform activity induced by either 4-aminopyridine or Mg(2+)-free medium alone. These observations demonstrate a role for Src family PTKs in the pathophysiology of epilepsy and suggest potential therapeutic targets for antiepileptic therapy.
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