ArticleProceedings of the National Academy of Sciences of the United States of America2000
Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 130 citations in OpenAlex.
- Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.Current Alzheimer research · 2009Trial
- Cholinergic status modulations in human volunteers under acute inflammation.Journal of molecular medicine (Berlin, Germany) · 2007Trial
- Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2006Trial
- Impact of Corn Oil on Biochemical and Neurochemical Markers in an Animal Model of Alzheimer's Disease.Neurology international · 2026Article
- Preliminary exploration of the expression of acetylcholinesterase in normal human T lymphocytes and leukemic Jurkat T cells.Biomedical reports · 2024Article
- Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs.Molecular psychiatry · 2022Article
- Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis.International journal of molecular sciences · 2021Review
- Article
- Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice.British journal of pharmacology · 2018Article
- α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.Scientific reports · 2017Article
- Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig.International journal of toxicology · 2016Article
- The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation.Journal of molecular neuroscience : MN · 2015Article
- Role of acetylcholinesterase in lung cancer.Thoracic cancer · 2015Review
- Acetylcholinesterase protein level is preserved in the Alzheimer's brain.Journal of molecular neuroscience : MN · 2014Article
- Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis.Advances in bioscience and biotechnology (Print) · 2013Article
- Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors?British journal of pharmacology · 2013Review
- Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.Brain structure & function · 2013Article
- Article
- Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis.Frontiers in molecular neuroscience · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute stress increases the risk for neurodegeneration, but the molecular signals regulating the shift from transient stress responses to progressive disease are not yet known. The "read-through" variant of acetylcholinesterase (AChE-R) accumulates in the mammalian brain under acute stress. Therefore, markers of neurodeterioration were examined in transgenic mice overexpressing either AChE-R or the "synaptic" AChE variant, AChE-S. Several observations demonstrate that excess AChE-R attenuates, whereas AChE-S intensifies, neurodeterioration. In the somatosensory cortex, AChE-S transgenics, but not AChE-R or control FVB/N mice, displayed a high density of curled neuronal processes indicative of hyperexcitation. In the hippocampus, AChE-S and control mice, but not AChE-R transgenics, presented progressive accumulation of clustered, heat shock protein 70-immunopositive neuronal fragments and displayed a high incidence of reactive astrocytes. Our findings suggest that AChE-R serves as a modulator that may play a role in preventing the shift from transient, acute stress to progressive neurological disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.