ArticleProceedings of the National Academy of Sciences of the United States of America2000
LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- 25-Hydroxycholesterol in health and diseases.Journal of lipid research · 2024Review
- Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers.Biomolecules · 2023Review
- Review
- Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC.Frontiers in oncology · 2020Article
- Increased Complement 3 With Suppression of miR-145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats.Journal of the American Heart Association · 2019Article
- Liver X receptors in lipid signalling and membrane homeostasis.Nature reviews. Endocrinology · 2018Review
- Juxtaglomerular Cell Phenotypic Plasticity.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
- E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro.Acta pharmaceutica Sinica. B · 2016Article
- Article
- Emerging role of liver X receptors in cardiac pathophysiology and heart failure.Basic research in cardiology · 2016Review
- Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.The Journal of biological chemistry · 2013Article
- Nuclear receptors and their selective pharmacologic modulators.Pharmacological reviews · 2013Review
- Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein.The Journal of biological chemistry · 2013Article
- Control of renin [corrected] gene expression.Pflugers Archiv : European journal of physiology · 2013Review
- PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance.PPAR research · 2013Review
- Liver X receptors and fat cell metabolism.International journal of obesity (2005) · 2012Review
- Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression.The Journal of biological chemistry · 2012Article
- Article
- cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.Pflugers Archiv : European journal of physiology · 2011Article
- Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.The Journal of biological chemistry · 2010Article
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Authors and funding
10 authors.
Funding
Abstract
LXRalpha is a member of a nuclear receptor superfamily that regulates transcription. LXRalpha forms a heterodimer with RXRalpha, another member of this family, to regulate the expression of cholesterol 7alpha-hydroxylase by means of binding to the DR4-type cis-element. Here, we describe a function for LXRalpha as a cAMP-responsive regulator of renin and c-myc gene transcriptions by the interaction with a specific cis-acting DNA element, CNRE (an overlapping cAMP response element and a negative response element). Our previous studies showed that renin gene expression is regulated by cAMP, at least partly, through the CNRE sequence in its 5'-flanking region. This sequence is also found in c-myc and several other genes. Based on our cloning results using the yeast one-hybrid system, we discovered that the mouse homologue of human LXRalpha binds to the CNRE and demonstrated that it binds as a monomer. To define the function of LXRalpha on gene expression, we transfected the renin-producing renal As4.1 cells with LXRalpha expression plasmid. Overexpression of LXRalpha in As4.1 cells confers cAMP inducibility to reporter constructs containing the renin CNRE. After stable transfection of LXRalpha, As4.1 cells show a cAMP-inducible up-regulation of renin mRNA expression. In parallel experiments, we demonstrated that LXRalpha can also bind to the homologous CNRE in the c-myc promoter. cAMP promotes transcription through c-myc/CNRE:LXRalpha interaction in LXRalpha transiently transfected cells and increases c-myc mRNA expression in stably transfected cells. Identification of LXRalpha as a cAMP-responsive nuclear modulator of renin and c-myc expression not only has cardiovascular significance but may have generalized implication in the regulation of gene transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.