ArticleMolecular psychiatry2000
Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population.
Article in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Pooled it
- GABRA6 gene polymorphism and an attenuated stress response.Molecular psychiatry · 2004Trial
- Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.Risk management and healthcare policy · 2025Article
- Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Article
- Polymorphisms of genes in neurotransmitter systems were associated with alcohol use disorders in a Tibetan population.PloS one · 2013Article
- The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.Psychopharmacology · 2009Review
- The role of GABA(A) receptors in the development of alcoholism.Pharmacology, biochemistry, and behavior · 2008Review
- Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
- Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder.The pharmacogenomics journal · 2005Article
- Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder.The pharmacogenomics journal · 2003Article
- Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.Molecular psychiatry · 2002Article
- The genetics of alcoholism and alcohol abuse.Current psychiatry reports · 2001Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)beta2, GABAAalpha6, GABA(A)alpha1 and two at the GABA(A)gamma2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)alpha6 receptor subunit gene and alcohol dependence (P = 0.059). However, the NciI RFLP at the GABA(A)gamma2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021). This supports a recent finding reporting an association between the GABA(A)gamma2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.