ArticleMolecular psychiatry2000
Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses.
Article in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Investigating the association between commonJournal of genetics · 2021Pooled it
- The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis.Behavioral and brain functions : BBF · 2016Pooled it
- The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Pooled it
- Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia.Molecular psychiatry · 2003Pooled it
- Targeting the Roots of Psychosis: The Role of Aberrant Salience.Pediatric reports · 2025Review
- Dopaminergic Epistases in Schizophrenia.Brain sciences · 2024Review
- Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.Schizophrenia bulletin · 2015Article
- Clinical and molecular genetics of psychotic depression.Schizophrenia bulletin · 2013Review
- Molecular genetics of the psychosis phenotype.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2012Review
- Monoamine oxidase a and B gene polymorphisms and negative and positive symptoms in schizophrenia.ISRN psychiatry · 2012Article
- Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors.International journal of environmental research and public health · 2011Article
- Identification of blood biomarkers for psychosis using convergent functional genomics.Molecular psychiatry · 2011Article
- Article
- The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia.Schizophrenia bulletin · 2008Article
- Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population.Behavioral and brain functions : BBF · 2007Article
- Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework.Molecular psychiatry · 2005Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The D2 receptor (DRD2) is a binding site of many psychoactive drugs and it has been proposed as a genetic risk factor for psychiatric disorders. The aim of this investigation was to study the DRD2 S311C variant in major psychoses. We studied 1182 inpatients with diagnoses of bipolar disorder (n = 480), major depressive disorder (n = 269), schizophrenia (n = 366), delusional disorder (n = 44), psychotic disorder not otherwise specified (n = 23) and 267 healthy controls. Eight hundred and eighty-seven subjects were also scored for their lifetime symptomatology using the the Operational Criteria checklist for psychotic illness (OPCRIT). DRD2 variants were not associated with affected subjects even when possible confounders like gender and onset were considered. When we considered the 887 subjects with the symptomatologic analysis, we observed a significant association of the DRD2 S311C variant with both delusion and disorganization features. The association was present independently from diagnoses. Our results do not show that coding variants of the DRD2 S311C play a major role in conferring susceptibility to major psychoses, but they may be connected with disorganized and delusional symptomatology independently from diagnoses.
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