Trial reportCirculation2000
Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators.
Trial report in Circulation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000463. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post Coronary Artery Bypass Graft (CABG) Study
Impact of Cholesterol Level on Long-term Angiographic Outcome of Coronary Artery Bypass Grafting
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Preoperative statin therapy for adults undergoing cardiac surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data: A Scoping Review and Analysis.JAMA network open · 2018Pooled it
- Baseline diabetes as a way to predict CV outcomes in a lipid-modifying trial: a meta-analysis of 330,376 patients from 47 landmark studies.Cardiovascular diabetology · 2015Pooled it
- Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies.BMJ (Clinical research ed.) · 2006 · on this mapPooled it
- Clinical implications of statin event trials.Current atherosclerosis reports · 2002Pooled it
- Impact of Warfarin and Dual Antiplatelet Therapy on Graft Failure After Coronary Endarterectomy: A Retrospective Cohort Study.Cardiovascular drugs and therapy · 2026Article
- Effect of Statin Intensity on Cardiovascular Outcomes and Survival Following Coronary Artery Bypass Grafting.Clinical cardiology · 2025Observational
- Nanomedicine-based strategies for the treatment of vein graft disease.Nature reviews. Cardiology · 2025Review
- The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.Lipids in health and disease · 2024Article
- Antithrombotic strategies for preventing graft failure in coronary artery bypass graft.Journal of thrombosis and thrombolysis · 2024Review
- The prognostic role of the low and very low baseline LDL-C level in outcomes of patients with cardiac revascularization; comparative registry-based cohort design.Journal of cardiothoracic surgery · 2023Article
- Influence of cholesterol level on long-term survival and cardiac events after surgical coronary revascularization.JTCVS open · 2022Article
- Intensive lipid-lowering therapy, time to think beyond low-density lipoprotein cholesterol.World journal of cardiology · 2021Review
- The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function.Cardiology research and practice · 2020Article
- Management of Saphenous Vein Graft Disease in Patients with Prior Coronary Artery Bypass Surgery.Current treatment options in cardiovascular medicine · 2019Review
- Does Early Graft Patency Benefit from Perioperative Statin Therapy? A Propensity Score-Matched Study of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery.Cardiovascular therapeutics · 2019Observational
- Current role of saphenous vein graft in coronary artery bypass grafting.Indian journal of thoracic and cardiovascular surgery · 2018Review
- The Role of Statins in the Management of Patients Undergoing Coronary Artery Bypass Grafting.Diseases (Basel, Switzerland) · 2018Review
- Management and Prevention of Saphenous Vein Graft Failure: A Review.Cardiology and therapy · 2017Review
- Use of the guidelines directed medical therapy after coronary artery bypass graft surgery in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe Post Coronary Artery Bypass Graft Trial, designed to compare the effects of 2 lipid-lowering regimens and low-dose anticoagulation versus placebo on progression of atherosclerosis in saphenous vein grafts of patients who had had CABG surgery, demonstrated that aggressive lowering of LDL cholesterol (LDL-C) levels to <100 mg/dL compared with a moderate reduction to 132 to 136 mg/dL decreased the progression of atherosclerosis in grafts. Low-dose anticoagulation did not significantly affect progression. METHODS AND
resultsApproximately 3 years after the last trial visit, Clinical Center Coordinators contacted each patient by telephone to ascertain the occurrence of cardiovascular events and procedures. The National Death Index was used to ascertain vital status for patients who could not be contacted. Vital status was established for all but 3 of 1351 patients. Information on nonfatal events was available for 95% of surviving patients. A 30% reduction in revascularization procedures and 24% reduction in a composite clinical end point were observed in patients assigned to aggressive strategy compared with patients assigned to moderate strategy during 7.5 years of follow-up, P=0. 0006 and 0.001, respectively. Reductions of 35% in deaths and 31% in deaths or myocardial infarctions with low-dose anticoagulation compared with placebo were also observed, P=0.008 and 0.003, respectively.
conclusions-The long-term clinical benefit observed during extended follow-up in patients assigned to the aggressive strategy is consistent with the angiographic findings of delayed atherosclerosis progression in grafts observed during the trial. The apparent long-term benefit of low-dose warfarin remains unexplained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.