ArticleJournal of virology2000
Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Role of Cellular Mechanisms in Dengue Pathogenesis: Focus on Immune Cells Interactions.Combinatorial chemistry & high throughput screening · 2026Review
- Innate Immune and Inflammatory Responses to Dengue Virus Infection.Current topics in microbiology and immunology · 2026Review
- Review
- Dysregulated immune cell responses in severe dengue pathogenesis.Frontiers in immunology · 2025Review
- Review
- The Dynamic Relationship between Dengue Virus and the Human Cutaneous Innate Immune Response.Viruses · 2024Review
- Viremia and Inflammatory Cytokines in Dengue: Interleukin-2 as a Biomarker of Infection, and Interferon-α and -γ as Markers of Primary versus Secondary Infection.Pathogens (Basel, Switzerland) · 2023Article
- The Current Landscape of Bioactive Molecules against DENV: A Systematic Review.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Zika Virus Replication in a Mast Cell Model is Augmented by Dengue Virus Antibody-Dependent Enhancement and Features a Selective Immune Mediator Secretory Profile.Microbiology spectrum · 2022Article
- Rescue therapy with intravenous immunoglobulin in severe refractory dengue: A pilot study.Medical journal, Armed Forces India · 2022Article
- Host immune response against DENV and ZIKV infections.Frontiers in cellular and infection microbiology · 2022Review
- Mast cells: Therapeutic targets for COVID-19 and beyond.IUBMB life · 2021Review
- Review
- Morphological Aspects and Viremia Analysis of BALB/c Murine Model Experimentally Infected with Dengue Virus Serotype 4.Viruses · 2021Article
- Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions.International journal of molecular sciences · 2021Review
- Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.Frontiers in medicine · 2021Article
- Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability.Viruses · 2020Article
- Mobilization and Activation of the Innate Immune Response to Dengue Virus.Frontiers in cellular and infection microbiology · 2020Review
- Safety, Immunogenicity, and Effectiveness of Defective Viral Particles Arising in Mast Cells Against Influenza in Mice.Frontiers in immunology · 2020Article
- Defective Viral Particles Produced in Mast Cells Can Effectively Fight Against Lethal Influenza A Virus.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the first demonstration of dengue virus infection and vasoactive cytokine response of a cell of the mast cell/basophil lineage. Infection of KU812 cells was dependent on dengue-specific antibody and gave rise to infectious virions. This antibody-enhanced dengue virus infection triggered a four- to fivefold increase in the release of interleukin-1beta (IL-1beta) and a modest increase for IL-6 but not for an alternate cytokine, granulocyte-macrophage colony-stimulating factor. The results suggest a potential role for mast cells/basophils in the pathogenesis of dengue virus-induced disease.
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Registered trials
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