ArticleJournal of virology2000
Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Genomic and morphological characterization of a novel iridovirus, bivalve iridovirus 1 (BiIV1), infecting the common cockle (Microbial genomics · 2025Article
- Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment.Nature communications · 2025Article
- The gammaherpesvirus 68 viral cyclin facilitates expression of LANA.PLoS pathogens · 2021Article
- Host Tumor Suppressor p18Journal of virology · 2018Article
- A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency.Journal of virology · 2015Article
- H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence.Journal of virology · 2013Article
- Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins.PLoS pathogens · 2012Article
- Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition.The Journal of biological chemistry · 2011Article
- Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation.Advances in virology · 2011Article
- Viral latency and its regulation: lessons from the gamma-herpesviruses.Cell host & microbe · 2010Review
- Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency.Journal of virology · 2010Article
- Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes.Journal of virology · 2009Article
- Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication.Virology · 2007Article
- Article
- Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin.Journal of virology · 2006Article
- Gamma interferon blocks gammaherpesvirus reactivation from latency.Journal of virology · 2006Article
- Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50).Journal of virology · 2005Article
- Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency.Journal of virology · 2005Article
- Immune regulation of viral infection and vice versa.Immunologic research · 2005Review
- Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine gammaherpesvirus 68 (MHV68) is a gammaherpesvirus that was first isolated from murid rodents. MHV68 establishes a latent infection in the spleen and other lymphoid organs. Several gammaherpesviruses, including herpesvirus saimiri, human herpesvirus 8, and MHV68, encode proteins with extensive homology to the D-type cyclins. To study the function of the cyclin homologue, a recombinant MHV68 has been constructed that lacks the cyclin homologue and expresses beta-galactosidase as a marker (MHV68(cy-)). MHV68(cy-) grows in vitro with kinetics and to titers similar to those of the wild type. BALB/c mice infected with mixtures of equivalent amounts of the wild type and MHV68(cy-) show deficient growth of the MHV68(cy-) in an acute infection. Infection of SCID mice with virus mixtures also showed decreased MHV68(cy-) virus growth, indicating that the deficiency is not mediated by T or B cells. Although mice infected with mixtures containing 100 times as much MHV68(cy-) had greater splenic titers of the mutant virus than wild-type virus in acute infection, at 28 days postinfection splenocytes from these mice reactivated primarily wild-type virus. Quantitative PCR data indicate that equivalent genomes were present in the latent state. Reinsertion of the cyclin homologue into the cyclin-deleted virus restored the wild-type phenotype. These results indicate that the MHV68 cyclin D homologue mediates important functions in the acute infection and is required for efficient reactivation from latency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.