ArticleMolecular and cellular biochemistry2000
The expression of insulin-like growth factor binding proteins in human hepatocellular carcinoma.
Article in Molecular and cellular biochemistry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Markers of liver regeneration-the role of growth factors and cytokines: a systematic review.BMC surgery · 2020Pooled it
- The Transplantation of Pancreatic Islets to Portal Vein: The Influence on Liver Tissue.International journal of molecular sciences · 2026Review
- IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.American journal of translational research · 2021Review
- Serum IGFBP-1 as a potential biomarker for diagnosis of early-stage upper gastrointestinal tumour.EBioMedicine · 2020Article
- Insulin-Like Growth Factor (IGF) System in Liver Diseases.International journal of molecular sciences · 2018Review
- Transcriptional activation of the IGF-II/IGF-1R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular carcinoma.Oncology letters · 2015Article
- Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Insulin-like growth factor binding protein-1 inhibits cancer cell invasion and is associated with poor prognosis in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2014Article
- The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets.Infectious agents and cancer · 2014Review
- Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.PloS one · 2013Article
- HBV induced HCC: major risk factors from genetic to molecular level.BioMed research international · 2013Review
- Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers.PloS one · 2012Article
- Involvement of insulin-like growth factor-binding protein-3 in the effects of histone deacetylase inhibitor MS-275 in hepatoma cells.The Journal of biological chemistry · 2011Article
- Targeting insulin-like growth factor axis in hepatocellular carcinoma.Journal of hematology & oncology · 2011Review
- Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma.Forum on immunopathological diseases and therapeutics · 2011Article
- Insulin-like growth factor binding protein-3 is required for the regulation of rat oval cell proliferation and differentiation in the 2AAF/PHX model.Hepatic medicine : evidence and research · 2010Article
- Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.World journal of gastroenterology · 2008Review
- [Molecular pathogenesis of hepatocellular carcinoma: new therapeutic approaches and predictive pathology].Der Pathologe · 2007Article
- High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.Cancer science · 2006Article
- Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin-like growth factors (IGF), IGF receptors and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. The liver is the major source of IGF-1 and at least two IGFBPs (IGFBP-1 and IGFBP-3). IGFBPs most often serve to attenuate the effects of IGF at the receptor level and thereby limit IGF-induced cell growth and differentiation. Although changes in IGFBP expression have been described during controlled liver growth such as hepatic regeneration following partial hepatectomy, there is limited knowledge of IGFBPs gene expression in uncontrolled growth or hepatocellular carcinoma. In the present study, we employed Northern blotting techniques to document the expression of IGFBP-1, 3 and 4 in normal human livers, cirrhotic and hepatocellular carcinoma tissues. The results revealed no differences in IGFBP-1, 3 and 4 mRNA levels between normal and cirrhotic tissues. However, the expression of all three IGFBPs mRNA were significantly down regulated in hepatocellular carcinoma tissues. These findings are in keeping with IGFBPs playing an important inhibitory role in the development and/or growth of hepatocellular carcinoma in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.