ReviewJournal of mammary gland biology and neoplasia1997
Prolactin mediated intracellular signaling in mammary epithelial cells.
Review in Journal of mammary gland biology and neoplasia, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation.Cell and tissue research · 2022Article
- Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity.The Journal of biological chemistry · 2016Article
- Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.Journal of lipid research · 2011Article
- The anti-metastatic nm23-1 gene is needed for the final step of mammary duct maturation of the mouse nipple.PloS one · 2011Article
- Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy.Molecular oncology · 2010Article
- What can we learn from rodents about prolactin in humans?Endocrine reviews · 2008Review
- The role of prolactin in mammary carcinoma.Endocrine reviews · 2003Review
- Prolactin and mammary gland development.Journal of mammary gland biology and neoplasia · 1999Review
- Control of normal mammary epithelial phenotype by integrins.Journal of mammary gland biology and neoplasia · 1998Review
- Prolactin as a mitogen in mammary cells.Journal of mammary gland biology and neoplasia · 1997Review
- Interactions of prolactin and growth hormone (GH) in the regulation of mammary gland function and epithelial cell survival.Journal of mammary gland biology and neoplasia · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin binds to a member of the cytokine receptor superfamily. The cytoplasmic domain of the prolactin receptor (PrlR) displays no enzymatic activity yet prolactin treatment leads to the induction of protein tyrosine phosphorylation. PrlR is associated with JAK2, a protein tyrosine kinase whose activity is stimulated following receptor dimerization. JAK2 subsequently phosphorylates PrlR and other cellular proteins which are recruited to the activated receptor complex. Among the JAK2 substrates is the transcription factor Stat5 whose phosphorylation mediates the transcriptional activation of beta-casein gene expression. In this review we discuss the prolactin induced signaling pathways which mediate differentiation of the mammary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.