ReviewJournal of mammary gland biology and neoplasia1997
The prolactin/growth hormone receptor family: structure/function relationships.
Review in Journal of mammary gland biology and neoplasia, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 131 citations in OpenAlex.
- Molecular characterization and functional analysis of buffalo prolactin (PRL) in mammary gland development and lactation.Archives animal breeding · 2025Article
- The Role of Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System.Frontiers in microbiology · 2022Review
- Article
- Article
- Connections between prolactin and ovarian cancer.PloS one · 2021Article
- Human Cytomegalovirus Infection Induces High Expression of Prolactin and Prolactin Receptors in Ovarian Cancer.Biology · 2020Article
- Preparation of a Growth Hormone Receptor/Prolactin Receptor Bispecific Antibody Antagonist Which Exhibited Anti-Cancer Activity.Frontiers in pharmacology · 2020Article
- Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Rapid Communication: Prolactin and hydrocortisone impact TNFα-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells.Journal of animal science · 2017Article
- Prolactin function and putative expression in the brain.Endocrine · 2017Review
- Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer Cells.Molecular endocrinology (Baltimore, Md.) · 2016Article
- The role of prolactin in andrology: what is new?Reviews in endocrine & metabolic disorders · 2015Review
- High expression of prolactin receptor is associated with cell survival in cervical cancer cells.Cancer cell international · 2013Article
- Interaction of JAK with steroid receptor function.JAK-STAT · 2013Review
- Lipopolysaccharide induces the expression of an autocrine prolactin loop enhancing inflammatory response in monocytes.Journal of inflammation (London, England) · 2013Article
- MiR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression.Molecules (Basel, Switzerland) · 2012Article
- Molecular mechanisms of prolactin and its receptor.Endocrine reviews · 2012Review
- The biology of progesterone receptor in the normal mammary gland and in breast cancer.Molecular and cellular endocrinology · 2012Review
- Prolactin regulation of the prostate gland: a female player in a male game.Nature reviews. Urology · 2011Review
- Mouse models of estrogen receptor-positive breast cancer.Journal of carcinogenesis · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin (PRL) and growth hormone (GH) receptors are members of the cytokine receptor superfamily that are activated by ligand-induced homodimerization. On the basis of this mechanism of activation, hormone antagonists have been developed that block the receptors in an inactive conformation. PRL and GH receptors are non-kinase receptors whose activation of signaling pathways requires participation of receptor-associated kinases, such as Janus kinases or Src kinases. Signal transduction by these receptors mainly involves the JAK/Stat pathway. In this review, we discuss the mechanism of ligand binding and receptor homodimerization as well as the involvement of molecules transducing the hormonal signal. Whenever possible, we attempt to correlate cytoplasmic features of the receptors with association and/or activation of transducer molecules or with a given biological property.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.