ReviewJournal of mammary gland biology and neoplasia1996
Latency and activation in the control of TGF-beta.
Review in Journal of mammary gland biology and neoplasia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 120 citations in OpenAlex.
- An agent-based model suggests how senescent cell behavior and matrix mechanics drive pulmonary fibrosis in aged mice.bioRxiv : the preprint server for biology · 2026Article
- Next-Generation Biomaterials for Vital Pulp Therapy: Exploring Biological Properties and Dentin Regeneration Mechanisms.Bioengineering (Basel, Switzerland) · 2025Review
- FLASH Radiotherapy: A FLASHing Idea to Preserve Neurocognitive Function.Brain tumor research and treatment · 2023Review
- The Role of TGF-β3 in Radiation Response.International journal of molecular sciences · 2023Review
- Exploiting Canonical TGFβ Signaling in Cancer Treatment.Molecular cancer therapeutics · 2022Review
- Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links.Biomolecules · 2021Review
- Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro.Antioxidants (Basel, Switzerland) · 2021Article
- Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish.iScience · 2020Article
- Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum.Scientific reports · 2019Article
- Misrepair in Context: TGFβ Regulation of DNA Repair.Frontiers in oncology · 2019Review
- Decorin inhibits the proliferation of HepG2 cells by elevating the expression of transforming growth factor-β receptor II.Experimental and therapeutic medicine · 2016Article
- Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.Cold Spring Harbor perspectives in biology · 2016Review
- Review
- Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer.Journal of mammary gland biology and neoplasia · 2014Review
- TGF- β: an important mediator of allergic disease and a molecule with dual activity in cancer development.Journal of immunology research · 2014Review
- Role of thrombospondin-1 in repair of penetrating corneal wounds.Investigative ophthalmology & visual science · 2013Article
- Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation.Cytokine & growth factor reviews · 2013Review
- Heme oxygenase-1 as a target for TGF-β in kidney disease.Seminars in nephrology · 2012Review
- Choreographing metastasis to the tune of LTBP.Journal of mammary gland biology and neoplasia · 2011Article
- Role of TGF-β signaling in inherited and acquired myopathies.Skeletal muscle · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The biological activity of the transforming growth factor-beta's (TGF-beta) is tightly controlled by their persistance in the extracellular compartment as latent complexes. Each of the three mammalian isoform genes encodes a product that is cleaved intracellularly to form two polypeptides, each of which dimerizes. Mature TGF-beta, a 24 kD homodimer, is noncovalently associated with the 80 kD latency-associated peptide (LAP). LAP is a fundamental component of TGF-beta that is required for its efficient secretion, prevents it from binding to ubiquitous cell surface receptors, and maintains its availability in a large extracellular reservoir that is readily accessed by activation. This latent TGF-beta complex (LTGF-beta) is secreted by all cells and is abundant both in circulating forms and bound to the extracellular matrix. Activation describes the collective events leading to the release of TGF-beta. Despite the importance of TGF-beta regulation of growth and differentiation in physiological and malignant tissue processes, remarkably little is known about the mechanisms of activation in situ. Recent studies of irradiated mammary gland reveal certain features of TGF-beta 1 activation that may shed light on its regulation and potential roles in the normal and neoplastic mammary gland.
Indexed as
Identifiers
10887509W1983332906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.