ReviewJournal of mammary gland biology and neoplasia1996
The role of TGF-beta in patterning and growth of the mammary ductal tree.
Review in Journal of mammary gland biology and neoplasia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues.Cell reports · 2023Article
- Local accumulation of extracellular matrix regulates global morphogenetic patterning in the developing mammary gland.Current biology : CB · 2021Article
- Higher plane of nutrition pre-weaning enhances Holstein calf mammary gland development through alterations in the parenchyma and fat pad transcriptome.BMC genomics · 2018Article
- Mechanisms of collective cell movement lacking a leading or free front edge in vivo.Cellular and molecular life sciences : CMLS · 2017Review
- Cellular foundations of mammary tubulogenesis.Seminars in cell & developmental biology · 2014Review
- Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype.Wiley interdisciplinary reviews. Membrane transport and signaling · 2014Article
- Three-dimensional cultures of mouse mammary epithelial cells.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway.Cancer research · 2012Article
- Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues.Biophysical journal · 2012Article
- Phospho-specific Smad3 signaling: impact on breast oncogenesis.Cell cycle (Georgetown, Tex.) · 2012Review
- Integrated morphodynamic signalling of the mammary gland.Nature reviews. Molecular cell biology · 2011Review
- Evaluation of mammary gland development and function in mouse models.Journal of visualized experiments : JoVE · 2011Article
- Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland.Journal of mammary gland biology and neoplasia · 2011Article
- miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.Nature genetics · 2010Article
- Loss of CD24 expression promotes ductal branching in the murine mammary gland.Cellular and molecular life sciences : CMLS · 2010Article
- Tissue remodelling through branching morphogenesis.Nature reviews. Molecular cell biology · 2009Review
- Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Endocrine reviews · 2009Review
- IGF-I, GH, and sex steroid effects in normal mammary gland development.Journal of mammary gland biology and neoplasia · 2008Article
- Prolactin regulation of mammary gland development.Journal of mammary gland biology and neoplasia · 2008Review
- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.Developmental biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Evidence that transforming growth factor beta (TGF-beta) influences pattern formation in the developing mammary gland and negatively regulates ductal growth is reviewed. In the mouse, overexpression of TGF-beta transgenes during puberty reduces the rate of growth of the ductal tree and simplifies the pattern of arborization, while expression during pregnancy also interferes with lactation. Expression studies in the normal mouse gland indicate that TGF-beta is synthesized in the mammary epithelium, with the three isoforms showing somewhat different spatial and temporal distributions. Exogenous TGF-beta applied directly to the gland in situ inhibits epithelial cell division within hours, and strongly stimulates extracellular matrix synthesis over a longer time course. Normal human breast cells as well as certain breast cancer cell lines also secrete TGF-beta and are themselves inhibited by it, suggesting an autoregulatory feedback circuit, that in some cases appears to be modulated by estradiol. Taken together, the evidence suggests a model in which growth and patterning of the mammary ductal tree are regulated, at least in part, by TGF-beta operating through an autocrine feedback mechanism and by paracrine circuits associated with epithelial-stromal interactions.
Indexed as
Identifiers
10887507What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.