ReviewJournal of mammary gland biology and neoplasia1996
Cell adhesion molecules in the normal and cancerous mammary gland.
Review in Journal of mammary gland biology and neoplasia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- 3D Modeling of Epithelial Tumors-The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology.International journal of molecular sciences · 2021Review
- Article
- Curvature-dependent constraints drive remodeling of epithelia.Journal of cell science · 2019Article
- Sinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation.Journal of anatomy · 2018Article
- Article
- Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle.PloS one · 2012Article
- Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells.Clinical & experimental metastasis · 2011Article
- The fur seal-a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution.Journal of mammary gland biology and neoplasia · 2007Review
- Strategies for engineering the adhesive microenvironment.Journal of mammary gland biology and neoplasia · 2004Review
- Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.The Journal of cell biology · 2004Article
- Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes.Breast cancer research : BCR · 2004Review
- Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells.Journal of cell science · 2003Article
- Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones.Endocrine-related cancer · 2000Review
- AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression.Molecular biology of the cell · 2000Article
- Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.Journal of mammary gland biology and neoplasia · 1999Review
- Tissue architecture: the ultimate regulator of epithelial function?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Establishment and initial characterization of the ovine mammary epithelial cell line NISH.In vitro cellular & developmental biology. Animal · 1998Article
- Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.Journal of mammary gland biology and neoplasia · 1998Review
- Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.The Journal of cell biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of normal tissue morphology is one of the first changes seen in the development of solid malignant tumours, including breast cancers. Since cell adhesion molecules play a crucial role in maintaining normal tissue architecture, investigations into the molecular mechanisms involved in the morphological changes occurring in malignancy that focus on the expression and function of cell adhesion molecules in malignant progression are extremely relevant. This review discusses the cadherin and integrin families of adhesion molecules which have been shown to be extremely important in the cell-cell and cell-matrix interactions of epithelial cells. Immunohistochemical studies using tissue and tumour sections indicate that a reduction in levels of expression or function of both types of cell adhesion molecules is indeed observed in many breast cancers. A specific and crucial role for these molecules in the maintenance of normal morphological differentiation has been demonstrated in vitro, where the noninvasive differentiated phenotype correlates with the normal functioning of E-Cadherin and alpha 2 beta 1 integrin. Further in vitro evidence suggests that in mammary epithelial cells, oncogenes may be upstream regulators of both the expression and function of E-Cadherin, the alpha 2 beta 1 integrin, and other epithelial specific molecules important for maintaining epithelial differentiation. In this way they could manifest their effects on the tumorigeneic potential of epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.