ReviewJournal of mammary gland biology and neoplasia1996
Cyclins and breast cancer.
Review in Journal of mammary gland biology and neoplasia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection.Human genomics · 2013Pooled it
- The Antitumour Mechanisms of Carotenoids: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2024Review
- Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.Science advances · 2023Article
- Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy.International journal of molecular sciences · 2022Review
- The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.Trends in cancer · 2017Review
- Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation.Ochsner journal · 2017Article
- Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer.Oncotarget · 2016Article
- Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions.Breast cancer research : BCR · 2014Review
- Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients.Medical oncology (Northwood, London, England) · 2012Article
- Dormant but migratory tumour cells in desmoplastic stroma of invasive ductal carcinomas.Clinical & experimental metastasis · 2012Article
- Key signaling nodes in mammary gland development and cancer: β-catenin.Breast cancer research : BCR · 2010Review
- Measuring proliferation in breast cancer: practicalities and applications.Breast cancer research : BCR · 2006Review
- Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?Breast cancer research : BCR · 2004Review
- Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Beta-catenin and Tcfs in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2003Review
- Retinoblastoma (RB1) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile.Journal of clinical pathology · 1998Article
- Mammary gland development and tumorigenesis in estrogen receptor knockout mice.Journal of mammary gland biology and neoplasia · 1997Review
- Prolactin as a mitogen in mammary cells.Journal of mammary gland biology and neoplasia · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in the understanding of cell cycle control by cyclins and cyclin-dependent kinases provide a basis for delineating the molecular mechanisms of proliferation control by steroids and the development and progression of hormone-dependent cancers. Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation. The cyclin D1 gene is amplified in approximately 15%, and its product overexpressed in 40-50%, of primary breast carcinomas. The strong evidence that cyclin D1 plays a major role in cell cycle control in breast epithelial cells suggests that its deregulated expression may have effects on disease progression and phenotype including sensitivity to endocrine therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.