ReviewJournal of mammary gland biology and neoplasia1996
Role of mesenchymal-epithelial interactions in mammary gland development.
Review in Journal of mammary gland biology and neoplasia, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 174 citations in OpenAlex.
- Embryonic Mammary Gland Morphogenesis.Advances in experimental medicine and biology · 2025Review
- Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.eLife · 2024Article
- Advances in Immunocompetent Mouse and Rat Models.Cold Spring Harbor perspectives in medicine · 2024Review
- Cancer as a Disease of Development Gone Awry.Annual review of pathology · 2024Review
- Review
- Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.Development (Cambridge, England) · 2023Article
- Epigenetic regulation of functional candidate genes for milk production traits in dairy sheep subjected to protein restriction in the prepubertal stage.BMC genomics · 2023Article
- Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis.Genome biology · 2018Article
- Preparation of epithelial cell aggregates incorporating matrigel microspheres to enhance proliferation and differentiation of epithelial cells.Regenerative therapy · 2017Article
- Preparation of EpH4 and 3T3L1 cells aggregates incorporating gelatin hydrogel microspheres for a cell condition improvement.Regenerative therapy · 2017Article
- Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.NPJ breast cancer · 2017Article
- Interplay of nuclear receptors (ER, PR, and GR) and their steroid hormones in MCF-7 cells.Molecular and cellular biochemistry · 2016Article
- Coordinated Action of Biological Processes during Embryogenesis Can Cause Genome-Wide Linkage Disequilibrium in the Human Genome and Influence Age-Related Phenotypes.Annals of gerontology and geriatric research · 2016Article
- The Dynamic Duo: Niche/Stem Cell Interdependency.Stem cell reports · 2015Review
- The Journal of Mammary Gland Biology and Neoplasia into the future - the potential of plasticity and pluripotency.Journal of mammary gland biology and neoplasia · 2015Article
- The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer.Advanced drug delivery reviews · 2014Review
- Glucocorticoids and microbiota regulate ontogeny of intestinal fucosyltransferase 2 requisite for gut homeostasis.Glycobiology · 2013Article
- Tissue recombination techniques for mouse embryonic mammary glands.Journal of mammary gland biology and neoplasia · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammary gland is a hormone-target organ derived from epidermis and develops as a result of reciprocal mesenchymal-epithelial interactions. The induction of mammary differentiation from indifferent epidermal cells by mammary mesenchyme implies induction of the complement of hormone receptors characteristic of normal mammary epithelium in cells of the epidermis. Considering the facts that mammary epithelial differentiation is induced by mammary mesenchyme and that certain aspects of hormone response (androgen-induced mammary regression) are inextricably linked to mesenchymal-epithelial interactions, it is evident that the biology of the mammary gland arises from and is maintained via cell-cell interactions. As a corollary, perturbation of stromal-epithelial interactions in adulthood may play a role in mammary carcinogenesis and in turn may provide opportunities for differentiation therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.