ArticleBrain pathology (Zurich, Switzerland)2000
Chromosomal imbalances in brain metastases of solid tumors.
Article in Brain pathology (Zurich, Switzerland), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Pioglitazone-Based Combination Approaches for Non-Small-Cell Lung Cancer.Pharmaceutics · 2025Review
- Chromosome-scale mega-haplotypes enable digital karyotyping of cancer aneuploidy.Nucleic acids research · 2017Article
- [Cancer of unknown primary. Epidemiology and pathogenesis].Der Radiologe · 2014Article
- Molecular determinants of lung cancer metastasis to the central nervous system.Translational lung cancer research · 2013Review
- E-cadherin as a predictive marker of brain metastasis in non-small-cell lung cancer, and its regulation by pioglitazone in a preclinical model.Journal of neuro-oncology · 2012Article
- Relevance of PTEN loss in brain metastasis formation in breast cancer patients.Breast cancer research : BCR · 2012Article
- Article
- Accurate classification of metastatic brain tumors using a novel microRNA-based test.The oncologist · 2011Article
- Pro-tumorigenic effects of miR-31 loss in mesothelioma.The Journal of biological chemistry · 2010Article
- [CUP syndrome: molecular pathogenesis and biology].Der Pathologe · 2009Article
- [Small cell lung cancer: pathology and molecular pathology].Der Pathologe · 2009Article
- Metastases in the Absence of a Primary Tumor: Advances in the Diagnosis and Treatment of CUP Syndrome.Deutsches Arzteblatt international · 2008Article
- Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.Translational oncogenomics · 2008Article
- Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China.World journal of gastroenterology · 2008Article
- Canine cytogenetics--from band to basepair.Cytogenetic and genome research · 2008Review
- Neuro-endocrine tumours of the lung. A review of relevant pathological and molecular data.Virchows Archiv : an international journal of pathology · 2007Review
- TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation.World journal of gastroenterology · 2007Article
- Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3.Neuro-oncology · 2005Article
- Chemotherapy for metastatic tumors to the central nervous system.Current oncology reports · 2001Review
- Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.Neoplasia (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastases account for approximately 50% of the malignant tumors in the brain. In order to identify structural alterations that are associated with tumor dissemination into the central nervous system we used Comparative Genomic Hybridization (CGH) to investigate 42 brain metastases and 3 primary tumors of 40 patients. The metastases originated from lung cancer (14 cases), melanomas (7), carcinomas of breast (5), colon (5), kidney (5), adrenal gland (1) and thyroid (1). In addition, tumors of initially unknown primaries were assessed in 3 cases. The highest incidence of DNA gains were observed for the chromosomal regions 1q23, 8q24, 17q24-q25, 20q13 (>80% of cases) followed by the gain on 7p12 (77%). DNA losses were slightly less frequent with 4q22, 4q26, 5q21, 9p21 being affected in at least 70% of the cases followed by deletions at 17p12, 4q32q34, 10q21, 10q23-q24 and 18q21-q22 in 67.5% of cases. Two unusual narrow regional peaks were observed for the gain on 17q24-q25 and loss on 17p12. The incidence at individual loci can be viewed at our CGH online tumor database at http:// amba.charite.de/cgh/. The metastases of each tumor type showed a recurrent pattern of changes. In those cases with primary tumor and metastases available, the CGH pattern exhibited a high degree of conformity. In conclusion, our data suggests that specific genetic lesions are associated with tumor dissemination into the nervous system and that CGH analysis may be a useful supplementary tool for classification of metastases with unknown origin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.