ArticleProceedings of the National Academy of Sciences of the United States of America2000
Two mechanisms for termination of individual Ca2+ sparks in skeletal muscle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- CaTrends in biochemical sciences · 2017Review
- Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle.The Journal of physiology · 2012Article
- Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle.The Journal of general physiology · 2012Article
- Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation.Journal of muscle research and cell motility · 2011Review
- Dynamic interreceptor coupling contributes to the consistent open duration of ryanodine receptors.Biophysical journal · 2009Article
- Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion.Circulation research · 2008Article
- Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians.The Journal of general physiology · 2008Article
- Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.American journal of physiology. Cell physiology · 2007Article
- Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers.The Journal of general physiology · 2006Article
- Depletion "skraps" and dynamic buffering inside the cellular calcium store.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Short-term regulation of excitation-contraction coupling by the beta1a subunit in adult mouse skeletal muscle.Biophysical journal · 2005Article
- Ca2+ sparks and secretion in dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Ca2+ blinks: rapid nanoscopic store calcium signaling.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The role of ryanodine receptors and consequences of their alterations during cardiac insufficiency.Experimental and clinical cardiology · 2005Article
- Intracellular Ca(2+) release as irreversible Markov process.Biophysical journal · 2002Article
- Comparison of simulated and measured calcium sparks in intact skeletal muscle fibers of the frog.The Journal of general physiology · 2002Article
- Calcium sparks in intact skeletal muscle fibers of the frog.The Journal of general physiology · 2001Article
- ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.The Journal of general physiology · 2001Article
- Calcium release in skeletal muscle: from K+ contractures to Ca2+ sparks.Journal of muscle research and cell motility · 2001Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ca(2+) sparks are brief, localized elevations of myoplasmic [Ca(2+)] caused by release of increments of Ca(2+) via sarcoplasmic reticulum Ca(2+) release channels in muscle. The properties of individual sparks provide information regarding the opening of sarcoplasmic reticulum Ca(2+) channels within functioning cells. Here we use high-speed confocal microscopy to show that individual Ca(2+) sparks activated by membrane depolarization in single frog skeletal muscle fibers can be terminated prematurely by repolarization. Thus, either voltage sensor deactivation on repolarization or release channel inactivation during continued depolarization can terminate the Ca(2+) release channel activity underlying voltage-activated Ca(2+) sparks in skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.