ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Properties and plasticity of paired-pulse depression at a central synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 110 citations in OpenAlex.
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- Enhanced Thalamocortical Synaptic Transmission and Dysregulation of the Excitatory-Inhibitory Balance at the Thalamocortical Feedforward Inhibitory Microcircuit in a Genetic Mouse Model of Migraine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Short-term synaptic depression can increase the rate of information transfer at a release site.PLoS computational biology · 2019Article
- Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.Developmental neurobiology · 2018Article
- Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- Functional motifs composed of morphologically homologous neurons repeated in the hindbrain segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- High concentrations of divalent cations isolate monosynaptic inputs from local circuits in the auditory midbrain.Frontiers in neural circuits · 2013Article
- Effects of Neonatal C-Fiber Depletion on Interaction between Neocortical Short-Term and Long-Term Plasticity.Basic and clinical neuroscience · 2013Article
- Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.Journal of neurophysiology · 2012Article
- Short-term presynaptic plasticity.Cold Spring Harbor perspectives in biology · 2012Review
- Developmental shift of short-term synaptic plasticity in cortical organotypic slices.Neuroscience · 2012Article
- Estimation of the time course of neurotransmitter release at central synapses from the first latency of postsynaptic currents.Journal of neuroscience methods · 2012Article
- Heterogeneous release probabilities and activity-dependent short-term synaptic depression.Communicative & integrative biology · 2011Article
- Article
- Atypical properties of release and short-term depression at a specialized nicotinic synapse in the Mauthner cell network.The Journal of experimental biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic depression was studied at the axo-axonic connection between the goldfish Mauthner axon and identified cranial relay interneurons using simultaneous presynaptic and postsynaptic recordings and a paired-pulse stimulus paradigm. We used interstimulus intervals (ISIs) ranging from 10 msec to 1 sec and a cycle time of approximately 5 sec. Depression (Delta EPSP/EPSP1) was maximal at the shorter intervals (80%) and decreased exponentially with a tau approximately 400 msec (360 +/- 107 msec, mean +/- SD). We found the amplitudes of the first and second EPSP were not correlated, indicating the magnitude of depression does not depend on the amount of transmitter released by the conditioning stimulus. At short ISIs, the latency of EPSP2 was 23% longer than that of EPSP1 and recovered to control with tau approximately 400 msec, whereas rise time and decay time were not altered significantly. The latency distribution, which is determined by the timing of the first quantum released each trial, was used to derive alpha(t), the rate of evoked exocytosis after an action potential. alpha(t) was biphasic, and both components were consistently delayed during depression. Presynaptic manipulations of putative intracellular regulatory pathways, such as Ca(2+) and GTPgammaS injections, preferentially affected the amplitude of EPSP1 or EPSP2. These results are not consistent with simple depletion of the available pool of synaptic vesicles as the major mechanism underlying depression. They rather suggest that it is attributable to a modification or refractoriness of the release process and that there may be multiple pathways subserving evoked exocytosis.
Indexed as
Identifiers
10884315PMC6772341W2165906862What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.