ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Light transduction in invertebrate hyperpolarizing photoreceptors: possible involvement of a Go-regulated guanylate cyclase.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Unusual phototransduction via cross-motif signaling from GProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- Phototransduction in a marine sponge provides insights into the origin of animal vision.iScience · 2022Article
- The Evolution of Visual Roles - Ancient Vision Versus Object Vision.Frontiers in neuroanatomy · 2022Article
- The evolution of red color vision is linked to coordinated rhodopsin tuning in lycaenid butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular Strategies for Intensity-Dependent Olfactory Processing inFrontiers in molecular neuroscience · 2021Article
- A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems.AIMS neuroscience · 2019Review
- Article
- Molecular and functional identification of a novel photopigment inThe Journal of general physiology · 2018Article
- Article
- Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin 1 and Their Influence on Spectral Tuning.The Journal of biological chemistry · 2015Article
- A Cyclic GMP-Dependent K+ Channel in the Blastocladiomycete Fungus Blastocladiella emersonii.Eukaryotic cell · 2015Article
- A rhodopsin-guanylyl cyclase gene fusion functions in visual perception in a fungus.Current biology : CB · 2014Article
- Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives.Journal of gastroenterology · 2014Review
- Article
- Arrestin in ciliary invertebrate photoreceptors: molecular identification and functional analysis in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cyclic nucleotide-gated channels are involved in phototransduction of dermal photoreceptors in Lymnaea stagnalis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- The evolution of phototransduction from an ancestral cyclic nucleotide gated pathway.Proceedings. Biological sciences · 2010Article
- C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.Nature neuroscience · 2010Article
- Complexes between photoactivated rhodopsin and transducin: progress and questions.The Biochemical journal · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hyperpolarizing receptor potential of scallop ciliary photoreceptors is attributable to light-induced opening of K(+)-selective channels. Having previously demonstrated the activation of this K(+) current by cGMP, we examined upstream events in the transduction cascade. GTP-gamma-S produced persistent excitation after a flash, accompanied by decreased sensitivity and acceleration of the photocurrent, whereas GDP-beta-S only inhibited responsiveness, consistent with the involvement of a G-protein. Because G(o) (but not G(t) nor G(q)) recently has been detected in the ciliary retinal layer of a related species, we tested the effects of activators of G(o); mastoparan peptides induced an outward current suppressible by blockers of the light-sensitive conductance such as l-cis-diltiazem. In addition, intracellular dialysis with the A-protomer of pertussis toxin (PTX) depressed the photocurrent. The mechanisms that couple G-protein stimulation to changes in cGMP were investigated. Intracellular IBMX enhanced the photoresponse with little effect on the baseline current, a result that argues against regulation by light of phosphodiesterase activity. LY83583, an inhibitor of guanylate cyclase (GC), exerted a reversible, dose-dependent suppression of the photocurrent. By contrast, ODQ, an antagonist of NO-sensitive GC, and YC-1, an activator of NO-sensitive GC, failed to alter the light response or the holding current; furthermore, the NO synthase inhibitor N-methyl- l-arginine was inert, indicating that the NO signaling pathway is not implicated. Taken together, these results suggest a novel type of phototransduction cascade in which stimulation of a PTX-sensitive G(o) may activate a membrane GC to induce an increase in cGMP and the consequent opening of light-dependent channels.
Indexed as
Identifiers
10884309PMC6772339W1833257145What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.