ArticleBritish journal of cancer2000
Fluorescence in situ hybridization techniques for the rapid detection of genetic prognostic factors in neuroblastoma. United Kingdom Children's Cancer Study Group.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study.BMC clinical pathology · 2014Article
- High level amplification of N-MYC is not associated with adverse histology or outcome in primary retinoblastoma tumours.British journal of cancer · 2002Article
- Fluorescence in situ hybridization in paraffin tissue sections: pretreatment protocol.Molecular biotechnology · 2002Article
- Methods of molecular analysis: assessing losses and gains in tumours.Molecular pathology : MP · 2002Review
- Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology.Brain pathology (Zurich, Switzerland) · 2002Review
- Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study.Neoplasia (New York, N.Y.)Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroblastoma is the commonest extracranial solid tumour in children. There are a number of molecular genetic features known which are of prognostic importance and which are used to direct therapy. Identification and targeting of high-risk individuals with intensive therapeutic regimens may allow an improvement in survival rates. The most powerful biological parameters associated with prognosis in this malignancy are chromosomal changes, especially MYCN amplification, deletion of chromosome 1p and aneuploidy. Rapid characterization of these aberrations at the time of diagnosis is paramount if stratification according to risk group is to be achieved. This paper describes the rapid detection of del(1p), MYCN amplification and trisomy using interphase fluorescence in situ hybridization on imprints from fresh tumour biopsies. The results are related to those obtained by standard molecular methods and karyotyping.
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