ArticleJournal of medical genetics2000
The ACE I allele is associated with increased risk for ruptured intracranial aneurysms.
Article in Journal of medical genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.Neurology · 2013Pooled it
- The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults.PloS one · 2008Pooled it
- Angiotensin Inhibition Reduces the Risk of Subarachnoid Hemorrhage in Patients With Hypertension.Stroke (Hoboken, N.J.) · 2025Article
- ACE-Triggered Hypertension Incites Stroke: Genetic, Molecular, and Therapeutic Aspects.Neuromolecular medicine · 2020Review
- Hypertension and longevity: role of genetic polymorphisms in renin-angiotensin-aldosterone system and endothelial nitric oxide synthase.Molecular and cellular biochemistry · 2019Observational
- Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis.Biomedical reports · 2017Article
- Article
- Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm.Molecular biology reports · 2012Article
- ACE genotype, risk and causal relationship to stroke: implications for treatment.Current treatment options in cardiovascular medicine · 2007Article
- The genetics of intracranial aneurysms.Journal of human genetics · 2006Review
- Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm.Journal of human genetics · 2003Article
- Introduction: Non-atherosclerotic cerebrovascular disorders.Brain pathology (Zurich, Switzerland) · 2002Review
- Mechanisms of abdominal aortic aneurysm formation.Current atherosclerosis reports · 2002Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic and environmental factors play roles in the aetiology of ruptured intracranial aneurysms. Hypertension has been reported as a risk factor for intracranial aneurysm haemorrhage. We have tested if genotypes at the angiotensin converting enzyme (ACE) gene locus are associated with ruptured intracranial aneurysms. The insertion/deletion polymorphism in the ACE gene was genotyped in 258 subjects presenting in East Anglia with ruptured intracranial aneurysms (confirmed at surgery or angiographically) and 299 controls from the same region. ACE allele frequencies were significantly different in the cases and the controls (alleles chi(2)(1)=4.67, p=0.03). The I allele was associated with aneurysm risk (odds ratio for I allele v D allele = 1.3 (95% CI=1.02-1-65); odds ratio for II v DD genotype = 1.67 (95% CI=1.04-2.66)). The I allele at the ACE locus is over-represented in subjects with ruptured intracranial aneurysms. These data are supported by non-significant trends in the same direction in two previous smaller studies. Thus, this allele may be associated with risk for ruptured intracranial aneurysms.
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Registered trials
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