ArticleClinical and diagnostic laboratory immunology2000
Primary structure of the sialodacryoadenitis virus genome: sequence of the structural-protein region and its application for differential diagnosis.
Article in Clinical and diagnostic laboratory immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Assessment of GO-Based Protein Interaction Affinities in the Large-Scale Human-Coronavirus Family Interactome.Vaccines · 2023Article
- Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data.PNAS nexus · 2022Article
- SDAV, the Rat Coronavirus-How Much Do We Know about It in the Light of Potential Zoonoses.Viruses · 2021Review
- Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and Wildlife.Viruses · 2021Review
- Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission.PloS one · 2021Article
- Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective.Animals : an open access journal from MDPI · 2020Review
- Effect of sialodacryoadenitis virus infection on axonal regeneration.Microsurgery · 2011Article
- A review of respiratory system anatomy, physiology, and disease in the mouse, rat, hamster, and gerbil.The veterinary clinics of North America. Exotic animal practice · 2011Review
- Molecular analysis of Brazilian strains of bovine coronavirus (BCoV) reveals a deletion within the hypervariable region of the S1 subunit of the spike glycoprotein also found in human coronavirus OC43.Archives of virology · 2006Article
- Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids.Journal of virology · 2004Article
- Recombinant viral sialate-O-acetylesterases.Glycoconjugate journal · 2004Article
- Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).Genomics, proteomics & bioinformatics · 2003Review
- Article
- A single amino acid change within antigenic domain II of the spike protein of bovine coronavirus confers resistance to virus neutralization.Clinical and diagnostic laboratory immunology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sialodacryoadenitis virus (SDAV) is a coronavirus that is commonly found in laboratory rats and that causes sialodacryoadenitis and respiratory illness. We cloned and sequenced the 3' terminal 9.8 kb of the genomic RNA and analyzed the structure of the viral genome. As with mouse hepatitis coronaviruses (MHVs), the SDAV genome was able to code for a spike protein, a small membrane protein, a membrane-associated protein, and a nucleocapsid protein. In addition, the hemagglutinin-esterase gene capable of encoding a protein of 439 amino acids (aa) was identified. The putative functional site for acetylesterase activity was present in the HE protein as Phe-Gly-Asp-Ser (FGDS), suggesting that the SDAV HE protein might have retained the esterase activity. Immediately upstream of the HE gene and downstream of the polymerase 1b gene, the NS2 nonstructural-protein gene was identified with a coding capacity of 274 aa. A motif of UCUAAAC was identified as a potential transcription signal for subgenomic mRNA synthesis. Large insertions of 172, 127, and 44 aa were detected in the N-terminal half of the predicted S protein of SDAV when its sequence was compared to the sequences of MHV 2, MHV JHM, and MHV A59, respectively. The sequence information on the SDAV S-protein gene was applied to a differential diagnostic PCR to detect and distinguish the rat coronavirus from mouse coronaviruses. This is the first report on the comprehensive genetic information of any rat coronavirus.
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