ArticleProceedings of the National Academy of Sciences of the United States of America2000
Microtubule self-organization is gravity-dependent.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health.International journal of molecular sciences · 2026Review
- Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity.Life (Basel, Switzerland) · 2026Article
- The effect of spaceflight on tissues of the spinal column.Bone reports · 2026Review
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Gravity-Induced Symmetry Breaking in Chemical Gardens.ACS omega · 2025Article
- Investigating the potential link between lunar cycle and multiple sclerosis relapses: a call for further studies.The Libyan journal of medicine · 2023Article
- Nonequilibrium Self-Assembly Time Forecasting by the Stochastic Landscape Method.The journal of physical chemistry. B · 2023Article
- Active matter in space.NPJ microgravity · 2022Review
- Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology.Biomedicines · 2022Article
- Microgravity Modifies the Phenotype of Fibroblast and Promotes Remodeling of the Fibroblast-Keratinocyte Interaction in a 3D Co-Culture Model.International journal of molecular sciences · 2022Article
- MRTF may be the missing link in a multiscale mechanobiology approach toward macrophage dysfunction in space.Frontiers in cell and developmental biology · 2022Article
- Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.Cellular and molecular life sciences : CMLS · 2021Article
- Gravitational Force-Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells.International journal of molecular sciences · 2021Article
- Review
- A minus-end directed kinesin motor directs gravitropism in Physcomitrella patens.Nature communications · 2021Article
- Bone fracture healing: perspectives according to molecular basis.Journal of bone and mineral metabolism · 2021Review
- Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity iniScience · 2020Article
- Sperm Motility of Mice under Simulated Microgravity and Hypergravity.International journal of molecular sciences · 2020Article
- Extreme Environmental Stress-Induced Biological Responses in the Planarian.BioMed research international · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although weightlessness is known to affect living cells, the manner by which this occurs is unknown. Some reaction-diffusion processes have been theoretically predicted as being gravity-dependent. Microtubules, a major constituent of the cellular cytoskeleton, self-organize in vitro by way of reaction-diffusion processes. To investigate how self-organization depends on gravity, microtubules were assembled under low gravity conditions produced during space flight. Contrary to the samples formed on an in-flight 1 x g centrifuge, the samples prepared in microgravity showed almost no self-organization and were locally disordered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.