ArticleThe Journal of experimental medicine2000
A B cell superantigen-induced persistent "Hole" in the B-1 repertoire.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
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- The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches.Cell reports. Medicine · 2024Article
- Integrating complex host-pathogen immune environments into S. aureus vaccine studies.Cell chemical biology · 2022Review
- The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immunoadsorption Improves Remission Rates of Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Severe Kidney Involvement.American journal of nephrology · 2021Article
- Immune and Inflammatory Determinants Underlying Alzheimer's Disease Pathology.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Article
- Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg's uncertainty principle to the verge of medical interventions.Mechanisms of ageing and development · 2020Review
- Autoimmune Cytopenias in Chronic Lymphocytic Leukemia: Focus on Molecular Aspects.Frontiers in oncology · 2019Review
- Essential Domain-Dependent Roles Within Soluble IgG forFrontiers in immunology · 2018Article
- Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.The Journal of experimental medicine · 2013Article
- Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Exploring Staphylococcus aureus pathways to disease for vaccine development.Seminars in immunopathology · 2012Review
- B cell development in GALT: role of bacterial superantigen-like molecules.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region.PloS one · 2009Article
- Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Quantum information processing in the wall of cytoskeletal microtubules.Journal of biological physics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The bacterial toxin protein A from Staphylococcus aureus (SpA) interacts with B cell antigen receptors encoded by variable region heavy chain (V(H)) clan III genes via a V region framework surface that has been highly conserved during the evolution of the adaptive immune system. We have investigated the consequences of exposure to this prototypic B cell superantigen, and found that treatment of neonates or adults induces a T cell-independent deletion of a large supraclonal set of susceptible B cells that includes clan III/V(H) S107 family-expressing lymphocytes. In studies of different SpA forms, the magnitude of the induced deletion directly correlated with the V(H)-specific binding affinity/avidity. Upon cessation of SpA exposure, the representation of conventional splenic (B-2 subset) lymphocytes normalized; however, we found that the V(H) family-restricted deficit of peritoneal B-1 cells persisted. SpA treatment also induced a persistent loss of splenic S107-mu transcripts, with a loss of certain natural antibodies and specific tolerance to phosphorylcholine immunogens that normally recruit protective antimicrobial responses dominated by the S107-expressing B-1 clone, T15. These studies illustrate how a B cell superantigen can exploit a primordial Achilles heel in the immune system, for which B-1 cells, an important source of natural antibodies and host immune responses, have special susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.