ArticleThe Journal of experimental medicine2000
The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.Frontiers in immunology · 2018Article
- Adriamycin resistance-associated prohibitin gene inhibits proliferation of human osteosarcoma MG63 cells by interacting with oncogenes and tumor suppressor genes.Oncology letters · 2016Article
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice.Clinical and experimental immunology · 2015Article
- A role for apoptosis-inducing factor in T cell development.The Journal of experimental medicine · 2012Article
- Article
- mTORC2 is required for proliferation and survival of TSC2-null cells.Molecular and cellular biology · 2011Article
- Multiple testing for gene sets from microarray experiments.BMC bioinformatics · 2011Article
- The Tumor Suppressor, p190RhoGAP, Differentially Initiates Apoptosis and Confers Docetaxel Sensitivity to Breast Cancer Cells.Genes & cancer · 2011Article
- Review
- Rho GTPase Cdc42 is essential for human T-cell development.Haematologica · 2010Article
- A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity.The Journal of experimental medicine · 2008Article
- BCL11B is required for positive selection and survival of double-positive thymocytes.The Journal of experimental medicine · 2007Article
- Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors.The Journal of experimental medicine · 2004Article
- Immunological function in mice lacking the Rac-related GTPase RhoG.Molecular and cellular biology · 2004Article
- Article
- T-cell antigen receptor signal transduction.Immunology · 2002Article
- RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.Oncogene · 2001Article
- Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo.The Journal of experimental medicine · 2001Article
- Impaired survival of T helper cells in the absence of CD4.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the early stages of thymopoiesis, cell survival is controlled by cytokines that regulate the expression of antiapoptotic proteins such as Bcl-2. At the pre-T cell stage, a critical checkpoint for beta chain selection is monitored by the tumor suppressor p53: pre-T cells can survive and differentiate when p53 is removed genetically or when its proapoptotic function is inactivated physiologically as a consequence of signaling through the pre-T cell receptor complex. Previous work has shown that the guanine nucleotide binding protein Rho controls cell survival in T cell progenitors. Here we define the survival pathways controlled by Rho in pre-T cells and show that this GTPase is a pivotal regulator of the p53-mediated checkpoint operating at the time of beta selection: loss of Rho function results in apoptosis in pre-T cells, but this cell death is prevented by loss of p53. The prevention of cell death by loss of p53 restored numbers of early T cell progenitors but did not fully restore thymic cellularity. Further analysis revealed that loss of Rho function caused survival defects in CD4/8 double-positive thymocytes that is independent of p53 but can be prevented by ectopic expression of Bcl-2. These studies highlight that the GTPase Rho is a crucial component of survival signaling pathways in at least two different thymocyte subpopulations: Rho controls the p53 survival checkpoint in pre-T cells and is also crucial for a p53 independent survival signaling pathway in CD4/8 double positives.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.