ArticleThe Journal of experimental medicine2000
Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 104 citations in OpenAlex.
- Virus-driven dysregulation of the BCR pathway: a potential mechanism for the high prevalence of HIV related B-cell lymphoma.Annals of hematology · 2024Review
- Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses.Journal of virology · 2018Article
- Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus.Journal of virology · 2018Article
- Autoimmunity checkpoints as therapeutic targets in B cell malignancies.Nature reviews. Cancer · 2018Review
- Kaposi sarcoma herpesvirus pathogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival.PLoS pathogens · 2016Article
- KSHV-Mediated Angiogenesis in Tumor Progression.Viruses · 2016Review
- K1 and K15 of Kaposi's Sarcoma-Associated Herpesvirus Are Partial Functional Homologues of Latent Membrane Protein 2A of Epstein-Barr Virus.Journal of virology · 2015Article
- Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi's sarcoma and non-Kaposi's cases.Journal of experimental & clinical cancer research : CR · 2015Article
- KSHV: pathways to tumorigenesis and persistent infection.Advances in virus research · 2014Review
- AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.Frontiers in immunology · 2012Article
- Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1.Oncogene · 2010Article
- Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.Cancer letters · 2010Review
- Mechanism of Fas signaling regulation by human herpesvirus 8 K1 oncoprotein.Journal of the National Cancer Institute · 2009Article
- Angiogenesis, Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus.Virologica Sinica · 2008Article
- A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus.PLoS pathogens · 2008Article
- Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K.Journal of virology · 2008Article
- Intracellular localization map of human herpesvirus 8 proteins.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The B cell antigen receptor (BCR) is a large complex that consists of a disulfide-linked tetramer of two transmembrane heavy (mu) chains and two light (lambda or kappa) chains in association with a heterodimer of Igalpha and Igbeta. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a transforming protein called K1, which has structural and functional similarity to Igalpha and Igbeta. We demonstrate that K1 downregulates the expression of BCR complexes on the surface. The NH(2)-terminal region of K1 specifically interacts with the mu chains of BCR complexes, and this interaction retains BCR complexes in the endoplasmic reticulum, preventing their intracellular transport to the cell surface. Thus, KSHV K1 resembles Igalpha and Igbeta in its ability to induce signaling and to interact with mu chains of the BCR. However, unlike Igalpha and Igbeta, which interact with mu chains to direct BCR complexes to the cell surface, K1 interacts with mu chains to block the intracellular transport of BCR complexes to the cell surface. These results demonstrate a unique feature of the K1 transforming protein, which may confer virus-infected cells with a long-term survival advantage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.