ArticleGenetics2000
courtless, the Drosophila UBC7 homolog, is involved in male courtship behavior and spermatogenesis.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Dynamic proteomics of Nasonia vitripennis pupal development reveals testis-specific regulation of new proteins (orphans) likely related to exo-α-sialidases.BMC genomics · 2026Article
- The role of ubiquitin-conjugating enzyme in the process of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2024Review
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- Ubiquitin-proteasome pathway annotation inGigaByte (Hong Kong, China) · 2022Article
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- Transcriptome Analysis of NPFR Neurons Reveals a Connection Between Proteome Diversity and Social Behavior.Frontiers in behavioral neuroscience · 2021Article
- The Drosophila DmGluRA is required for social interaction and memory.Frontiers in pharmacology · 2013Article
- A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development.Molecular & cellular proteomics : MCP · 2011Article
- The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating.PloS one · 2011Article
- Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue.Biogerontology · 2010Article
- Age, but not experience, affects courtship gene expression in male Drosophila melanogaster.PloS one · 2009Article
- Gene discovery in an invasive tephritid model pest species, the Mediterranean fruit fly, Ceratitis capitata.BMC genomics · 2008Article
- A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success.Genetics · 2006Article
- Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases.Molecular biology of the cell · 2004Article
- The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing.Genes & development · 2002Article
- Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.Genome biology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The courtless (col) mutation disrupts early steps of courtship behavior in Drosophila males, as well as the development of their sperm. Most of the homozygous col/col males (78%) do not court at all. Only 5% perform the entire ritual and copulate, yet these matings produce no progeny. The col gene maps to polytene chromosome band 47D. It encodes two proteins that differ in their carboxy termini and are the Drosophila homologs of the yeast ubiquitin-conjugating enzyme UBC7. The col mutation is caused by an insertion of a P element into the 3' UTR of the gene, which probably disrupts translational regulatory elements. As a consequence, the homozygous mutants exhibit a six- to sevenfold increase in the level of the COL protein. The col product is essential, and deletions that remove the col gene are lethal. During embryonic development col is expressed primarily in the CNS. Our results implicate the ubiquitin-mediated system in the development and function of the nervous system and in meiosis during spermatogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.