ArticleThe American journal of pathology2000
Human decidua contains potent immunostimulatory CD83(+) dendritic cells.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 198 citations in OpenAlex.
- Immune dysregulation linking pre-pregnancy obesity to gestational diabetes mellitus.Frontiers in immunology · 2026Review
- Human Decidual CD1aInternational journal of molecular sciences · 2023Article
- Three Oxidative Stress-Related Genes That Associate Endometrial Immune Cells Are Considered as Potential Biomarkers for the Prediction of Unexplained Recurrent Implantation Failure.Frontiers in immunology · 2022Article
- The Role and Clinical Interest of Extracellular Vesicles in Pregnancy and Ovarian Cancer.Biomedicines · 2021Review
- TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance.Frontiers in immunology · 2021Article
- Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation.International journal of molecular sciences · 2020Review
- Decidualization Process Induces Maternal Monocytes to Tolerogenic IL-10-Producing Dendritic Cells (DC-10).Frontiers in immunology · 2020Article
- Role of the NLRP3 Inflammasome in Preeclampsia.Frontiers in endocrinology · 2020Review
- Immunometabolism, pregnancy, and nutrition.Seminars in immunopathology · 2018Review
- Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface.Genome research · 2017Article
- Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation.Cell adhesion & migration · 2016Review
- Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity.Journal of pregnancy · 2016Review
- Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells.The Journal of endocrinology · 2015Article
- An immunohistochemical study of CD83- and CD1a-positive dendritic cells in the decidua of women with recurrent spontaneous abortion.European journal of medical research · 2015Article
- T helper cell mediated-tolerance towards fetal allograft in successful pregnancy.Clinical and molecular allergy : CMA · 2015Article
- Toxoplasma gondii infection of decidual CD1c(+) dendritic cells enhances cytotoxicity of decidual natural killer cells.Inflammation · 2014Article
- Myeloid decidual dendritic cells and immunoregulation of pregnancy: defective responsiveness to Coxiella burnetii and Brucella abortus.Frontiers in cellular and infection microbiology · 2014Article
- T cell behavior at the maternal-fetal interface.The International journal of developmental biology · 2014Review
- Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia.Frontiers in immunology · 2014Review
- Role of the innate immunity in female reproductive tract.Advanced biomedical research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are sentinel cells of the immune system important in initiating antigen-specific T-cell responses to microbial and transplantation antigens. DCs are particularly found in surface tissues such as skin and mucosa, where the organism is threatened by infectious agents. The human decidua, despite its proposed immunosuppressive function, hosts a variety of immunocompetent CD45 cells such as natural killer cells, macrophages, and T cells. Here we describe the detection, isolation, and characterization of CD45(+), CD40(+), HLA-DR(++), and CD83(+) cells from human early pregnancy decidua with typical DC morphology. CD83(+) as well as CD1a(+) cells were found in close vicinity to endometrial glands, with preference to the basal layer of the decidua. In vitro, decidual CD83(+) cells could be enriched to approximately 30%, with the remainder of cells encompassing DC-bound CD3(+) T cells. Stimulation of allogeneic T cells in a mixed leukocyte reaction by the decidual cell fraction enriched for CD83(+) cells, was similar to that obtained with blood monocyte-derived DCs, demonstrating the potent immunostimulatory capacity of these cells. Decidual DCs with morphological, phenotypic, and functional characteristics of immunostimulatory DCs might be important mediators in the regulation of immunological balance between maternal and fetal tissue, leading to successful pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.