ArticleThe American journal of pathology2000
Platelet production in the pulmonary capillary bed: new ultrastructural evidence for an old concept.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 147 citations in OpenAlex.
- Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study.Pharmacological research · 2020Trial
- Pulmonary Arterial Hypertension Requiring Medication Is Associated With Higher Prevalence of Thrombocytopenia in Pediatric Patients.Pediatric pulmonology · 2025Article
- Time-Dependent Changes in Pulmonary Turnover of Thrombocytes During Critical COVID-19.Critical care explorations · 2024Article
- Highly efficient platelet generation in lung vasculature reproduced by microfluidics.Nature communications · 2023Article
- Megakaryocytes in the lung: History and future perspectives.Research and practice in thrombosis and haemostasis · 2023Article
- Chemotherapy-induced thrombocytopenia: literature review.Discover oncology · 2023Review
- Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2023Review
- A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.Journal of cell science · 2022Article
- The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis.Experimental hematology & oncology · 2022Review
- Occurrence and role of lung megakaryocytes in infection and inflammation.Frontiers in immunology · 2022Review
- Platelet Detection Based on Improved YOLO_v3.Cyborg and bionic systems (Washington, D.C.) · 2022Article
- Mitochondrial dynamics and reactive oxygen species initiate thrombopoiesis from mature megakaryocytes.Blood advances · 2021Article
- Lung megakaryocytes display distinct transcriptional and phenotypic properties.Blood advances · 2020Article
- Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- Review
- Platelet activation in experimental murine neonatal pulmonary hypertension.Physiological reports · 2020Article
- Neonatal platelet count trends during inhaled nitric oxide therapy.British journal of haematology · 2020Article
- On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications.Frontiers in immunology · 2020Review
- Platelet Biogenesis in the Lung Circulation.Physiology (Bethesda, Md.) · 2019Review
- Biological Characteristics and Regulation of Early Megakaryocytopoiesis.Stem cell reviews and reports · 2019Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there is substantial evidence indicating that platelets are released from megakaryocytes in the capillary bed of the lung, this concept has not been universally accepted because much of the evidence has been indirect. To more definitively substantiate that platelet production takes place in the lungs, megakaryocyte and platelet production was accelerated in mice by phlebotomy or by administration of thrombopoietin, and ultrastructural analysis was performed on lung specimens. Intact megakaryocytes, megakaryocyte fragments with numerous demarcated platelet fields, dissociating intact platelets, and denuded megakaryocyte nuclei were seen in the pulmonary capillaries of mice. In addition, some megakaryocyte nuclei exhibited the morphological counterpart of apoptosis. These observations provide evidence for platelet release in the capillary bed of the lungs during stimulated as well as reactive thrombocytosis without precluding observations that some "proplatelets" form in the sinusoids of the bone marrow before transmigration of intact megakaryocytes into the circulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.