Trial reportThe Journal of physiology2000
Ageing, muscle properties and maximal O(2) uptake rate in humans.
Trial report in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02417428 (Effects of Citrulline Supplementation Combined With Exercise on Muscle Function and Functional Capacity in Older Obese Men and Women), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Citrulline Supplementation Combined With Exercise on Muscle Function and Functional Capacity in Older Obese Men and Women
Who cites it
45 citing papers in PubMed, 125 citations in OpenAlex.
- Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects.Endocrine journal · 2025Trial
- Acute effect of dietary nitrate on forearm muscle oxygenation, blood volume and strength in older adults: A randomized clinical trial.PloS one · 2017Trial
- Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals.The Journal of clinical endocrinology and metabolism · 2017Trial
- Age differences in physiological responses to self-paced and incremental [Formula: see text] testing.European journal of applied physiology · 2017Trial
- Skeletal muscle NAMPT is induced by exercise in humans.American journal of physiology. Endocrinology and metabolism · 2010Trial
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.Age and ageing · 2026Article
- Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.The Journal of physiology · 2025Article
- The diagnostic agreement of sarcopenic obesity with different definitions in Chinese community-dwelling middle-aged and older adults.Frontiers in public health · 2024Article
- Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Implication of diet and exercise on the management of age-related sarcopenic obesity in Asians.Geriatrics & gerontology international · 2022Review
- Metabolic cost in healthy fit older adults and young adults during overground and treadmill walking.European journal of applied physiology · 2021Article
- Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing.The Journal of physiology · 2021Article
- Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia.Journal of translational medicine · 2021Review
- Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease-The Union of Two Culprits.Life (Basel, Switzerland) · 2021Review
- Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty.JCI insight · 2020Article
- Linking epidemiology and molecular mechanisms in sarcopenic obesity in populations.The Proceedings of the Nutrition Society · 2020Article
- Benefit-to-Risk Balance of Weight Loss Interventions in Older Adults with Obesity.Current diabetes reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
This paper asks how the decline in maximal O(2) uptake rate (VO(2),max) with age is related to the properties of a key muscle group involved in physical activity - the quadriceps muscles. Maximal oxygen consumption on a cycle ergometer was examined in nine adult (mean age 38.8 years) and 39 elderly subjects (mean age 68.8 years) and compared with the oxidative capacity and volume of the quadriceps. VO(2),max declined with age between 25 and 80 years and the increment in oxygen consumption from unloaded cycling to VO(2),max (delta VO(2)) in the elderly was 45 % of the adult value. The cross-sectional areas of the primary muscles involved in cycling - the hamstrings, gluteus maximus and quadriceps - were all lower in the elderly group. The quadriceps volume was reduced in the elderly to 67 % of the adult value. Oxidative capacity per quadriceps volume was reduced to 53 % of the adult value. The product of oxidative capacity and muscle volume - the quadriceps oxidative capacity - was 36 % of the adult value in the elderly. Quadriceps oxidative capacity was linearly correlated with delta VO(2) among the subjects with the slope indicating that the quadriceps represented 36 % of the VO(2) increase during cycling. The decline in quadriceps oxidative capacity with age resulted from reductions in both muscle volume and oxidative capacity per volume in the elderly and appears to be an important determinant of the age-related reduction in delta VO(2) and VO(2),max found in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.