ArticleJournal of clinical microbiology2000
Molecular typing of Mycobacterium tuberculosis based on variable number of tandem DNA repeats used alone and in association with spoligotyping.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Review
- Exploring the "Latin American Mediterranean" family and the RDBMC microbiology · 2019Article
- Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa.mBio · 2015Article
- Genomics and Machine Learning for Taxonomy Consensus: The Mycobacterium tuberculosis Complex Paradigm.PloS one · 2015Article
- Current methods in the molecular typing of Mycobacterium tuberculosis and other mycobacteria.BioMed research international · 2014Review
- Use of genotyping based clustering to quantify recent tuberculosis transmission in Guadeloupe during a seven years period: analysis of risk factors and access to health care.BMC infectious diseases · 2013Article
- Rapid deletion-based subtyping system for the Manila family of Mycobacterium tuberculosis.Journal of clinical microbiology · 2011Article
- Investigation on Mycobacterium tuberculosis diversity in China and the origin of the Beijing clade.PloS one · 2011Article
- Use of cluster-graphs from spoligotyping data to study genotype similarities and a comparison of three indices to quantify recent tuberculosis transmission among culture positive cases in French Guiana during a eight year period.BMC infectious diseases · 2008Article
- Progression toward an improved DNA amplification-based typing technique in the study of Mycobacterium tuberculosis epidemiology.Journal of clinical microbiology · 2006Article
- Molecular diagnostics in tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Review
- Efficient differentiation of Mycobacterium tuberculosis strains of the W-Beijing family from Russia using highly polymorphic VNTR loci.European journal of epidemiology · 2005Article
- Characterization of ancestral Mycobacterium tuberculosis by multiple genetic markers and proposal of genotyping strategy.Journal of clinical microbiology · 2004Article
- High rates of clustering of strains causing tuberculosis in Harare, Zimbabwe: a molecular epidemiological study.Journal of clinical microbiology · 2004Article
- Molecular epidemiology of Mycobacterium tuberculosis in western Sweden.Journal of clinical microbiology · 2004Article
- Mycobacterial interspersed repetitive unit typing of Mycobacterium tuberculosis compared to IS6110-based restriction fragment length polymorphism analysis for investigation of apparently clustered cases of tuberculosis.Journal of clinical microbiology · 2003Article
- Evaluation and utilization as a public health tool of a national molecular epidemiological tuberculosis outbreak database within the United Kingdom from 1997 to 2001.Journal of clinical microbiology · 2003Article
- DNA fingerprinting of Salmonella enterica subsp. enterica serovar typhimurium with emphasis on phage type DT104 based on variable number of tandem repeat loci.Journal of clinical microbiology · 2003Article
- Development of variable-number tandem repeat typing of Mycobacterium bovis: comparison of results with those obtained by using existing exact tandem repeats and spoligotyping.Journal of clinical microbiology · 2002Article
- Spoligotype diversity of Mycobacterium bovis strains isolated in France from 1979 to 2000.Journal of clinical microbiology · 2001Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fingerprinting based on variable numbers of tandem DNA repeats (VNTR), a recently described methodology, was evaluated for molecular typing of Mycobacterium tuberculosis in an insular setting. In this study, VNTR fingerprinting was used alone or as a second-line test in association with spoligotyping, double-repetitive-element PCR (DRE-PCR), and IS6110 restriction fragment length polymorphism (RFLP) analysis, and the discriminatory power for each method or the combination of methods was compared by calculating the Hunter-Gaston discriminative index (HGI). The results obtained showed that in 6 out of 12 (50%) cases, VNTR-defined clusters were further subdivided by spoligotyping, compared to 7 out of 18 (39%) cases where spoligotyping-defined clusters were further subdivided by VNTR. When used alone, VNTR was the least discriminatory method (HGI = 0.863). Although VNTR was significantly more discriminatory when used in association with spoligotyping (HGI = 0.982), the combination of spoligotyping and DRE-PCR (HGI = 0.992) was still the most efficient among rapid, PCR-based methodologies, giving results comparable to IS6110 RFLP analysis. Nonetheless, VNTR typing may provide additional phylogenetical information that may be helpful to trace the molecular evolution of tubercle bacilli.
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