ArticleAmerican journal of human genetics2000
Localization of multiple melanoma tumor-suppressor genes on chromosome 11 by use of homozygosity mapping-of-deletions analysis.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells.Nature communications · 2026Article
- Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma.PloS one · 2017Article
- Copy number variation in archival melanoma biopsies versus benign melanocytic lesions.Cancer biomarkers : section A of Disease markers · 2016Article
- Article
- LOH analysis of free DNA in the plasma of patients with mucosal malignant melanoma in the head and neck.International journal of clinical oncology · 2007Article
- Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays.PLoS computational biology · 2006Article
- Article
- The C677T methylenetetrahydrofolate reductase variant and third trimester obstetrical complications in women with unexplained elevations of maternal serum alpha-fetoprotein.Reproductive biology and endocrinology : RB&E · 2004Article
- Circulating DNA microsatellites: molecular determinants of response to biochemotherapy in patients with metastatic melanoma.Journal of the National Cancer Institute · 2004Article
- Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer.Molecular pathology : MP · 2003Article
- Analysis of DLC-1 expression in human breast cancer.Journal of cancer research and clinical oncology · 2003Article
- Deletion, mutation, and loss of expression of KLF6 in human prostate cancer.The American journal of pathology · 2003Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Loss-of-heterozygosity (LOH) studies have implicated one or more chromosome 11 tumor-suppressor gene(s) in the development of cutaneous melanoma as well as a variety of other forms of human cancer. In the present study, we have identified multiple independent critical regions on this chromosome by use of homozygosity mapping of deletions (HOMOD) analysis. This method of analysis involved the use of highly polymorphic microsatellite markers and statistics to identify regions of hemizygous deletion in unmatched melanoma cell line DNAs. Regions of loss were defined by the presence of an extended region of homozygosity (ERH) at > or =5 adjacent markers and having a statistical probability of < or =.001. Significant ERHs were similar in nature to deletions identified by LOH analyses performed on uncultured melanomas, although a higher frequency of loss (24 [60%] of 40 vs. 16 [34%] of 47) was observed in the cell lines. Overall, six small regions of overlapping deletions (SROs) were identified on chromosome 11 flanked by the markers D11S1338/D11S907 (11p13-15.5 [SRO1]), D11S1344/D11S11385 (11p11.2 [SRO2]), D11S917/D11S1886 (11q21-22.3 [SRO3]), D11S927/D11S4094 (11q23 [SRO4]), AFM210ve3/D11S990 (11q24 [SRO5]), and D11S1351/D11S4123 (11q24-25 [SRO6]). We propose that HOMOD analysis can be used as an adjunct to LOH analysis in the localization of tumor-suppressor genes.
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