Evidence map›Paper›PMID 10874742›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2000

The immune responses to bacterial antigens encountered in vivo at mucosal surfaces.

G Dougan, M Ghaem-Maghami, D Pickard, G Frankel, G Douce, S Clare, S Dunstan, C Simmons

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G DouganDepartment of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK. g.dougan@ic.ac.uk
M Ghaem-Maghami
D Pickard
G Frankel
G Douce
S Clare
S Dunstan
C Simmons

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non-living mucosal vaccines and immunostimulators.

Indexed as

Adjuvants, ImmunologicAnimalsAnti-Bacterial AgentsAntigens, BacterialBacterial VaccinesCitrobacterDisease Models, AnimalEnterobacteriaceae InfectionsEnterotoxinsHumansImmunity, MucosalMiceMucous MembraneAdjuvants, ImmunologicAnti-Bacterial AgentsAntigens, BacterialBacterial VaccinesEnterotoxins

Identifiers

PMID10874742
PMCPMC1692779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.