ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2000
Quorum sensing and the population-dependent control of virulence.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.
- A bibliometric analysis on discovering anti-quorum sensing agents against clinically relevant pathogens: current status, development, and future directions.Frontiers in microbiology · 2023Pooled it
- Decoding the gut interactome after severe trauma: from molecular dialogue to integrative treatment strategies.Frontiers in microbiology · 2026Review
- Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors inJournal of enzyme inhibition and medicinal chemistry · 2023Article
- Quorum Sensing Is Required for the Colony Establishment of a Plant Phyllosphere Bacterium Rhodopseudomonas palustris Strain GJ-22.Applied and environmental microbiology · 2023Article
- Design, Synthesis, and Biological Evaluation of Phenyloxadiazole Sulfoxide Derivatives as PotentMolecules (Basel, Switzerland) · 2023Article
- Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model.Entropy (Basel, Switzerland) · 2023Article
- SdiA Enhanced the Drug Resistance ofFrontiers in microbiology · 2022Article
- Article
- Naringenin Inhibition of theFrontiers in molecular biosciences · 2020Article
- Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution.Nature microbiology · 2019Article
- Quorum sensing by farnesol revisited.Current genetics · 2017Review
- Antifouling Compounds from Marine Macroalgae.Marine drugs · 2017Review
- Growth rate, transmission mode and virulence in human pathogens.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Characterization of N-Acyl Homoserine Lactones in Vibrio tasmaniensis LGP32 by a Biosensor-Based UHPLC-HRMS/MS Method.Sensors (Basel, Switzerland) · 2017Article
- Specificity and complexity in bacterial quorum-sensing systems.FEMS microbiology reviews · 2016Review
- Effects of an inducible aiiA gene on disease resistance in Eucalyptus urophylla × Eucalyptus grandis.Transgenic research · 2016Article
- Article
- Impairment of Pseudomonas aeruginosa Biofilm Resistance to Antibiotics by Combining the Drugs with a New Quorum-Sensing Inhibitor.Antimicrobial agents and chemotherapy · 2015Article
- Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy.BMC systems biology · 2015Article
- Bacterial social interactions drive the emergence of differential spatial colony structures.BMC systems biology · 2015Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One crucial feature of almost all bacterial infections is the need for the invading pathogen to reach a critical cell population density sufficient to overcome host defences and establish the infection. Controlling the expression of virulence determinants in concert with cell population density may therefore confer a significant survival advantage on the pathogen such that the host is overwhelmed before a defence response can be fully initiated. Many different bacterial pathogens are now known to regulate diverse physiological processes including virulence in a cell-density-dependent manner through cell-cell communication. This phenomenon, which relies on the interaction of a diffusible signal molecule (e.g. an N-acylhomoserine lactone) with a sensor or transcriptional activator to couple gene expression with cell population density, has become known as 'quorum sensing'. Although the size of the 'quorum' is likely to be highly variable and influenced by the diffusibility of the signal molecule within infected tissues, nevertheless quorum-sensing signal molecules can be detected in vivo in both experimental animal model and human infections. Furthermore, certain quorum-sensing molecules have been shown to possess pharmacological and immunomodulatory activity such that they may function as virulence determinants per se. As a consequence, quorum sensing constitutes a novel therapeutic target for the design of small molecular antagonists capable of attenuating virulence through the blockade of bacterial cell-cell communication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.