ArticleThe British journal of ophthalmology2000
Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy.
Article in The British journal of ophthalmology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Management after cataract surgery for patients with diabetic retinopathy: a systematic review and meta-analysis.International ophthalmology · 2024Pooled it
- Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor.Clinical and translational science · 2021Trial
- Phase 1/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Trial
- Prostanoid signaling in retinal cells elicits inflammatory responses relevant to early-stage diabetic retinopathy.Journal of neuroinflammation · 2024Article
- Diabetic Retinopathy: Soluble and Imaging Ocular Biomarkers.Journal of clinical medicine · 2023Review
- Inflammatory and angiogenic biomarkers in diabetic retinopathy.Biochemia medica · 2020Review
- Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization.FASEB bioAdvances · 2020Article
- CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization.JCI insight · 2019Article
- Assessment of biomarkers using multiplex assays in aqueous humor of patients with diabetic retinopathy.BMC ophthalmology · 2017Article
- Regulatory SNPs Alter the Gene Expression of Diabetic Retinopathy Associated Secretary Factors.International journal of medical sciences · 2016Article
- Effect of shRNA-mediated knockdown of vascular endothelial growth factor on the proliferation of choroid-retinal endothelial cells under hypoxic conditions.Experimental and therapeutic medicine · 2015Article
- Diabetic Retinopathy: Vascular and Inflammatory Disease.Journal of diabetes research · 2015Review
- Modulation of CD44 Activity by A6-Peptide.Frontiers in immunology · 2015Review
- Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion.PloS one · 2015Article
- Gene expression of IGF1, IGF1R, and IGFBP3 in epiretinal membranes of patients with proliferative diabetic retinopathy: preliminary study.Mediators of inflammation · 2013Article
- Novel targets against retinal angiogenesis in diabetic retinopathy.Current diabetes reports · 2012Review
- A chronic grey matter penumbra, lateral microvascular intussusception and venous peduncular avulsion underlie diabetic vitreous haemorrhage.The British journal of ophthalmology · 2007Review
- Diabetic cataract removal: postoperative progression of maculopathy--growth factor and clinical analysis.The British journal of ophthalmology · 2006Article
- Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.Investigative ophthalmology & visual science · 2004Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocyte growth factor (HGF) is an endothelium specific growth factor that has been implicated in angiogenesis, a crucial event for the development of proliferative diabetic retinopathy (PDR). The aim of the study is to determine the intravitreous concentrations of HGF in diabetic patients with PDR, and to investigate whether its serum levels could contribute to its intravitreous concentration.
methods17 diabetic patients and seven non-diabetic patients in whom a vitrectomy was performed were studied. Both groups were matched by serum levels of HGF. Venous blood and vitreous samples were collected simultaneously at the time of vitreoretinal surgery. Vitreous and serum HGF were determined by ELISA.
resultsIntravitreous concentrations of HGF (median and range) were higher in diabetic patients (17.04 ng/ml (9.98-80)) in comparison with non-diabetic patients (5.88 ng/ml (2.57-14.20); p=0. 003). Intravitreous HGF concentrations were strikingly higher than serum HGF concentrations both in diabetic patients (17.04 ng/ml (9. 98-80) v 0.66 ng/ml (0.26-1.26); p<0.001) and in the control group (5.88 ng/ml (2.57-14.20) v 0.68 ng/ml (0.49-0.96); p=0.003). No correlation was found between serum and vitreous levels of HGF in both groups (diabetic patients, r= -0.31; p=0.5 and control subjects r= -0.15; p=0.5).
conclusionThe high vitreous levels of HGF observed in diabetic patients with PDR cannot be attributed to serum diffusion across the blood-retinal barrier. Therefore, intraocular synthesis appears to be the main contributing factor for the high vitreous HGF concentrations in diabetic patients, a cytokine that seems to be directly involved in the pathogenesis of PDR.
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