ArticleGene therapy2000
Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.
Article in Gene therapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 123 citations in OpenAlex.
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- A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme.Bioactive materials · 2023Article
- Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.Frontiers in oncology · 2021Review
- Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit.Synthetic biology (Oxford, England) · 2021Review
- Advances in Molecular Mechanisms and Treatment of Radiation-Induced Pulmonary Fibrosis.Translational oncology · 2019Review
- In Vivo Radioprotective Activity of Cell-Permeable Bifunctional Antioxidant Enzyme GST-TAT-SOD against Whole-Body Ionizing Irradiation in Mice.Oxidative medicine and cellular longevity · 2017Article
- Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures.Oncotarget · 2016Article
- GST-TAT-SOD: Cell Permeable Bifunctional Antioxidant Enzyme-A Potential Selective Radioprotector.Oxidative medicine and cellular longevity · 2016Article
- Subcutaneous administration of bovine superoxide dismutase protects lungs from radiation-induced lung injury.Free radical research · 2015Article
- Gene therapy for radioprotection.Cancer gene therapy · 2015Review
- Antioxidant Approaches to Management of Ionizing Irradiation Injury.Antioxidants (Basel, Switzerland) · 2015Article
- Nanoparticle-based targeted therapeutics in head-and-neck cancer.International journal of medical sciences · 2015Review
- Alpha-2-macroglobulin as a radioprotective agent: a review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Review
- Radioprotection of normal tissue cells.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Review
- New approaches to radiation protection.Frontiers in oncology · 2014Review
- Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines.Radiation research · 2013Article
- Apparent polyploidization after gamma irradiation: pitfalls in the use of quantitative polymerase chain reaction (qPCR) for the estimation of mitochondrial and nuclear DNA gene copy numbers.International journal of molecular sciences · 2013Article
- Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.BMC cancer · 2012Article
- Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency.Seminars in cell & developmental biology · 2012Review
- Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
To determine whether intratracheal (IT) lung protective manganese superoxide-plasmid/liposomes (MnSOD-PL) complex provided 'bystander' protection of thoracic tumors, mice with orthotopic Lewis lung carcinoma-bacterial beta-galactosidase gene (3LL-LacZ) were studied. There was no significant difference in irradiation survival of 3LL-LacZ cells irradiated, then cocultured with MnSOD-PL-treated compared with control lung cells (D0 2.022 and 2.153, respectively), or when irradiation was delivered 24 h after coculture (D0 0.934 and 0.907, respectively). Tumor-bearing control mice showed 50% survival at 18 days and 10% survival at 21 days. Mice receiving liposomes with no insert or LacZ-PL complex plus 18 Gy had 50% survival at 22 days, and a 20% and 30% survival at day 50, respectively. Mice receiving MnSOD-PL complex followed by 18 Gy showed prolonged survival of 45% at 50 days after irradiation (P < 0.001). Nested RT-PCR assay for the human MnSOD transgene demonstrated expression at 24 h in normal lung, but not in orthotopic tumors. Decreased irradiation induction of TGF-beta1, TGF-beta2, TGF-beta3, MIF, TNF-alpha, and IL-1 at 24 h was detected in lungs, but not orthotopic tumors from MnSOD-PL-injected mice (P < 0.001). Thus, pulmonary radioprotective MnSOD-PL therapy does not provide detectable 'bystander' protection to thoracic tumors.
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