ArticleNucleic acids research2000
HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- The RP11-417E7.1/THBS2 signaling pathway promotes colorectal cancer metastasis by activating the Wnt/β-catenin pathway and facilitating exosome-mediated M2 macrophage polarization.Journal of experimental & clinical cancer research : CR · 2024Article
- HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation.Nature communications · 2023Article
- HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA-less cancer cells.Cancer science · 2023Article
- Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis.Molecular cell · 2021Article
- Article
- Decreased Expression of a Gene Caused by a T-DNA Insertion in an Adjacent Gene in Arabidopsis.PloS one · 2016Article
- Distant activation of transcription: mechanisms of enhancer action.Molecular and cellular biology · 2012Review
- Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription.Genes & development · 2011Article
- Cis-regulation of microRNA expression by scaffold/matrix-attachment regions.Nucleic acids research · 2011Article
- Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.Genes & development · 2010Article
- Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein.Genes & cancer · 2010Article
- Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1.PLoS pathogens · 2009Article
- Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains.Journal of virology · 2009Article
- Sox6 directly silences epsilon globin expression in definitive erythropoiesis.PLoS genetics · 2006Article
- Large-scale structural analysis of the core promoter in mammalian and plant genomes.Nucleic acids research · 2005Article
- Computational approaches to identify promoters and cis-regulatory elements in plant genomes.Plant physiology · 2003Review
- HMG-I(Y) and the CBP/p300 coactivator are essential for human papillomavirus type 18 enhanceosome transcriptional activity.Molecular and cellular biology · 2003Article
- Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases.Nucleic acids research · 2002Article
- GAGA can mediate enhancer function in trans by linking two separate DNA molecules.The EMBO journal · 2002Article
- The HMG I proteins: dynamic roles in gene activation, development, and tumorigenesis.Immunologic research · 2001Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The nature of nuclear structures that are required to confer transcriptional regulation by distal enhancers is unknown. We show that long-range enhancer-dependent beta-globin transcription is achieved in vitro upon addition of the DNA architectural protein HMG I/Y to affinity-enriched holo RNA polymerase II complexes. In this system, HMG I/Y represses promoter activity in the absence of an associated enhancer and strongly activates transcription in the presence of a distal enhancer. Importantly, nucleosome formation is neither necessary for long-range enhancer regulation in vitro nor sufficient without the addition of HMG I/Y. Thus, the modulation of DNA structure by HMG I/Y is a critical regulator of long-range enhancer function on both DNA and chromatin-assembled genes. Electron microscopic analysis reveals that HMG I/Y binds cooperatively to preferred DNA sites to generate distinct looped structures in the presence or absence of the beta-globin enhancer. The formation of DNA topologies that enable distal enhancers to strongly regulate gene expression is an intrinsic property of HMG I/Y and naked DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.