ArticleNucleic acids research2000
Retrotransposition of the I factor, a non-long terminal repeat retrotransposon of Drosophila, generates tandem repeats at the 3' end.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Dynamic and intricate regulation by the Csr sRNAs in the Arctic Pseudoalteromonas fuliginea.Communications biology · 2025Article
- Cross-Kingdom Commonality of a Novel Insertion Signature of RTE-Related Short Retroposons.Genome biology and evolution · 2018Article
- Rescuing Alu: recovery of new inserts shows LINE-1 preserves Alu activity through A-tail expansion.PLoS genetics · 2012Article
- The diversity of retrotransposons and the properties of their reverse transcriptases.Virus research · 2008Review
- A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.PLoS biology · 2007Article
- Article
- Secondary structure models of the 3' untranslated regions of diverse R2 RNAs.RNA (New York, N.Y.) · 2004Article
- A non-long terminal repeat retrotransposon family is restricted to the germ line micronucleus of the ciliated protozoan Tetrahymena thermophila.Eukaryotic cell · 2004Article
- Gene silencing triggered by non-LTR retrotransposons in the female germline of Drosophila melanogaster.Genetics · 2003Article
- The esterase and PHD domains in CR1-like non-LTR retrotransposons.Molecular biology and evolution · 2003Article
- Article
- Human L1 element target-primed reverse transcription in vitro.The EMBO journal · 2002Article
- Molecular archeology of L1 insertions in the human genome.Genome biology · 2002Article
- Chimeric RNA transposition intermediates of the I factor produce precise retrotransposed copies.Nucleic acids research · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Non-long terminal repeat (LTR) retrotransposons or LINEs transpose by reverse transcription of an RNA intermediate and are thought to use the 3' hydroxyl of a chromosomal cleavage to initiate synthesis of the first strand of the cDNA. Many of them terminate in a poly(dA) sequence at the 3' end of the coding strand although some, like the I factor of Drosophila melanogaster, have 3' ends formed by repeats of the trinucleotide TAA. We report results showing that I factor transcripts end a few nucleotides downstream of the TAA repeats and that these extra nucleotides are not integrated into chromosomal DNA during retrotransposition. We also show that the TAA repeats are not required for transposition and that I elements containing mutations affecting the TAA sequences generate transposed copies ending with tandem repeats of various types. Our results suggest that during integration the 3' end of the I factor RNA template can pair with nucleotides at the target site and that tandem duplications are generated by the reverse transcriptase of the I factor in a manner that is reminiscent of the activity of the reverse transcriptases of telomerases. Reverse transcriptases of other non-LTR retrotransposons may function in a similar way.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.