ArticleProceedings of the National Academy of Sciences of the United States of America2000
pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression.Nature communications · 2025Article
- E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.Nature communications · 2025Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer.International journal of molecular sciences · 2022Article
- Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4-pRB Axis in Fibroblasts at the Invasive Tumor Edge.Cancer research · 2022Article
- The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.Nature communications · 2021Article
- Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mutation profile of non-small cell lung cancer revealed by next generation sequencing.Respiratory research · 2021Article
- E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice.Animals : an open access journal from MDPI · 2020Article
- Article
- E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs.Genomics data · 2015Article
- Reorganization of the host epigenome by a viral oncogene.Genome research · 2012Article
- E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.The Journal of experimental medicine · 2011Article
- Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Cell stem cell · 2010Review
- The retinoblastoma protein modulates Tbx2 functional specificity.Molecular biology of the cell · 2010Article
- The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.EMBO reports · 2007Article
- The LIM-only protein FHL2 is a negative regulator of E4F1.Oncogene · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retinoblastoma protein pRB is involved in the transcriptional control of genes essential for cell cycle progression and differentiation. pRB interacts with different transcription factors and thereby modulates their activity by sequestration, corepression, or activation. We report that pRB, but not p107 and p130, binds to and facilitates repression by p120(E4F), a ubiquitously expressed GLI-Kruppel-related protein identified as a cellular target of E1A. The interaction involves two distinct regions of p120(E4F) and the C-terminal part of pRB. In vivo pRB-p120(E4F) complexes can only be detected in growth-arrested cells, and accordingly contain the hypophosphorylated form of pRB. Repression of an E4F-responsive promoter is strongly increased by combined expression of p120(E4F) and pRB, which correlates with pRB-dependent enhancement of p120(E4F) binding activity. Elevated levels of p120(E4F) have been shown to block growth of mouse fibroblasts in G(1). We find this requires pRB, because RB(-/-) fibroblasts are significantly less sensitive to excess p120(E4F).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.