SynthesisArchives of disease in childhood2000
Corticosteroid therapy in nephrotic syndrome: a meta-analysis of randomised controlled trials.
Synthesis in Archives of disease in childhood, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Corticosteroid therapy for nephrotic syndrome in children.The Cochrane database of systematic reviews · 2024Pooled it
- Corticosteroid therapy for nephrotic syndrome in children.The Cochrane database of systematic reviews · 2020Pooled it
- Corticosteroid therapy for nephrotic syndrome in children.The Cochrane database of systematic reviews · 2015Pooled it
- Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome.Journal of the American Society of Nephrology : JASN · 2013Trial
- The treatment of relapsing primary nephrotic syndrome in children.Journal of Zhejiang University. Science. B · 2005Trial
- Treatment Outcomes of Pediatric Nephrotic Syndrome Patients Treated in Ayder Comprehensive Specialized and Mekelle General Hospitals, Ethiopia.International journal of nephrology and renovascular disease · 2021Article
- The safety and efficacy of mycophenolate mofetil in children and adolescents with steroid-dependent nephrotic syndrome: a single-centre study.Clinical kidney journal · 2020Article
- MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome.European journal of clinical pharmacology · 2019Article
- Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness.Sudanese journal of paediatrics · 2019Article
- A randomized study on a 3-month versus a 7-month prednisolone regimen for the initial episode of childhood idiopathic nephrotic syndrome at a large Saudi center.International journal of pediatrics & adolescent medicine · 2018Article
- Corticosteroids for the initial episode of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods.Canadian journal of kidney health and disease · 2014Article
- A single-centre retrospective study of the safety and efficacy of mycophenolate mofetil in children and adolescents with nephrotic syndrome.Clinical kidney journal · 2013Article
- Pharmacotherapeutic review and update of idiopathic nephrotic syndrome in children.Pharmacy world & science : PWS · 2010Review
- Treatment aspects of primary nephrotic syndrome in adults.Bosnian journal of basic medical sciences · 2006Article
- Evidence-based management of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2005Review
- Treatment of steroid sensitive nephrotic syndrome.Indian journal of pediatrics · 2005Review
- Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved?Pediatric nephrology (Berlin, Germany) · 2005Article
- The effects of corticosteroids on behavior in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2003Article
- Long versus standard initial steroid therapy for children with the nephrotic syndromeA report from the Southwest Pediatric Nephrology Study Group.Pediatric nephrology (Berlin, Germany) · 2003Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the benefits and toxicity of different corticosteroid regimes in preventing relapse in steroid responsive nephrotic syndrome.
designMeta-analysis of randomised controlled trials. SUBJECTS: Twelve trials involving 868 children aged 3 months to 18 years.
main outcome measureFrequency of relapse.
resultsA meta-analysis of five trials, which compared two months of prednisone with three months or more in the first episode, showed that the longer duration significantly reduced the risk of relapse at 12-24 months (relative risk 0.73; 95% confidence interval 0.60 to 0.89) without an increase in adverse events. There was an inverse linear relation (relative risk 1.382 (SE 0.215) - 0.133 (SE 0.048) duration; r(2) = 0.66; p = 0.05) between the duration of treatment and risk of relapse.
conclusionsChildren in their first episode of steroid responsive nephrotic syndrome should be treated with prednisone for at least three months, with an increase in benefit being shown for up to seven months of treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.