ArticleBiophysical journal2000
Regulation of the type III InsP(3) receptor by InsP(3) and ATP.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Calcium and arrhythmogenesis.Physiological reviews · 2007Pooled it
- Conformational motions and ligand-binding underlying gating and regulation in IPNature communications · 2022Article
- Review
- Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function.World journal of gastroenterology · 2019Review
- Polycystin 2 regulates mitochondrial CaScience signaling · 2019Article
- Cardiac inositol 1,4,5-trisphosphate receptors.Biochimica et biophysica acta. Molecular cell research · 2017Review
- Calcium signaling and the secretory activity of bile duct epithelia.Cell calcium · 2014Review
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation.The Journal of biological chemistry · 2011Article
- Mathematical model of mouse embryonic cardiomyocyte excitation-contraction coupling.The Journal of general physiology · 2008Article
- Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus.Journal of neuroscience research · 2007Article
- Spontaneously active and InsP3-activated ion channels in cell nuclei from rat cerebellar Purkinje and granule neurones.The Journal of physiology · 2005Article
- Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.Biophysical journal · 2005Article
- Nuclear and cytosolic calcium are regulated independently.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Regulation by Ca2+ and inositol 1,4,5-trisphosphate (InsP3) of single recombinant type 3 InsP3 receptor channels. Ca2+ activation uniquely distinguishes types 1 and 3 insp3 receptors.The Journal of general physiology · 2001Article
- ATP regulation of recombinant type 3 inositol 1,4,5-trisphosphate receptor gating.The Journal of general physiology · 2001Article
- Subtype-specific regulation of inositol 1,4,5-trisphosphate receptors: controlling calcium signals in time and space.The Journal of general physiology · 2001Review
- ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.The Journal of general physiology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many hormones and neurotransmitters raise intracellular calcium (Ca(2+)) by generating InsP(3) and activating the inositol 1,4, 5-trisphosphate receptor (InsP(3)R). Multiple isoforms with distinct InsP(3) binding properties () have been identified (). The type III InsP(3)R lacks Ca(2+)-dependent inhibition, a property that makes it ideal for signal initiation (). Regulation of the type III InsP(3)R by InsP(3) and ATP was explored in detail using planar lipid bilayers. In comparison to the type I InsP(3)R, the type III InsP(3)R required a higher concentration of InsP(3) to reach maximal channel activity (EC(50) of 3.2 microM versus 0.5 microM for the types III and I InsP(3)R, respectively). However, the type III InsP(3)R did reach a 2.5-fold higher level of activity. Although activation by InsP(3) was isoform-specific, regulation by ATP was similar for both isoforms. In the presence of 2 microM InsP(3), low ATP concentrations (<6 mM) increased the open probability and mean open time. High ATP concentrations (>6 mM) decreased channel activity. These results illustrate the complex nature of type III InsP(3)R regulation. Enhanced channel activity in the presence of high InsP(3) may be important during periods of prolonged stimulation, whereas allosteric modulation by ATP may help to modulate intracellular Ca(2+) signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.