Evidence map›Paper›PMID 10864969›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000

Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells.

B Halabisky, D Friedman, M Radojicic, B W Strowbridge

Abstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Adenosine AFrontiers in cellular neuroscience · 2017
    Article
  16. Review
  17. Article
  18. Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  19. Distinct roles of bulbar muscarinic and nicotinic receptors in olfactory discrimination learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

B HalabiskyDepartment of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106-4975, USA.
D Friedman
M Radojicic
B W Strowbridge

Funding

Synaptic Plasticity in Hippocampal Mossy CellsR01NS033590 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI STROWBRIDGE, BEN W · 2002 to 2006
$1.3M
SYNAPTIC PLASTICITY IN HIPPOCAMPAL MOSSY CELLSR29NS033590 · NINDS · UNIVERSITY OF WASHINGTON · PI STROWBRIDGE, BEN W · 1995 to 1999
–
NINDS NIH HHS NS 33590NINDS NIH HHS R01 NS033590NINDS NIH HHS R29 NS033590
6 · The paper itself

Abstract

Recurrent inhibition in olfactory bulb mitral cells is mediated via reciprocal dendrodendritic synapses with granule cells. Although GABAergic granule cells express both NMDA and non-NMDA glutamate receptors, dendrodendritic inhibition (DDI) relies on the activation of NMDA receptors. Using whole-cell recordings from rat olfactory bulb slices, we now show that olfactory NMDA receptors have a dual role; they depolarize granule cell spines, and they provide a source of calcium that can evoke GABA exocytosis. We demonstrate that exogenous NMDA can trigger GABA release after blockade of voltage-dependent calcium channels (VDCCs) with Cd. We also find that postsynaptic depolarization alone can evoke GABA release via a separate mechanism that relies on calcium influx through Cd-sensitive VDCCs. By selectively manipulating postsynaptic responses in granule cells with high-K or low-Na extracellular solutions, we show that endogenous glutamate can elicit GABA release via both NMDA receptor- and VDCC-dependent pathways. Finally, we find that blockade of Na channels in granule cells with tetrodotoxin enhances DDI, presumably by reducing the depolarization of granule cells during DDI and thereby increasing the driving force for Ca entry through NMDA receptors. These results provide evidence of a novel mechanism for evoked transmitter release that depends on Ca influx through ionotropic receptors and provides a new potential site for synaptic plasticity in the olfactory bulb.

Indexed as

2-Amino-5-phosphonovalerateAnimalsCadmiumCalciumCalcium ChannelsDendritesElectric StimulationExcitatory Amino Acid Antagonistsgamma-Aminobutyric AcidIn Vitro TechniquesMagnesiumN-MethylaspartateOlfactory BulbQuinoxalinesRatsRats, Sprague-Dawley2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline2-Amino-5-phosphonovalerateCadmiumCalciumCalcium ChannelsExcitatory Amino Acid AntagonistsFG 9041gamma-Aminobutyric AcidMagnesiumN-MethylaspartateQuinoxalinesReceptors, GlutamateReceptors, N-Methyl-D-AspartateVirulence Factors, Bordetella

Identifiers

PMID10864969
PMCPMC6772283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.