ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 160 citations in OpenAlex.
- Neural correlates underlying micrographia in Parkinson's disease.Brain : a journal of neurology · 2016Trial
- Programmed axon degeneration: from mouse to mechanism to medicine.Nature reviews. Neuroscience · 2020Review
- Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- The acute toxic and neurotoxic effects of 3,4-methylenedioxymethamphetamine are more pronounced in adolescent than adult mice.Behavioural brain research · 2020Article
- Catecholaminergic axons in the neocortex of adult mice regrow following brain injury.Experimental neurology · 2020Article
- Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.PLoS genetics · 2019Article
- Divergent Expression Patterns of Drp1 and HSD10 in the Nigro-Striatum of Two Mice Strains Based on their MPTP Susceptibility.Neurotoxicity research · 2019Article
- MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer's Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance.Molecular neurobiology · 2019Article
- Evaluation of exercise-induced modulation of glial activation and dopaminergic damage in a rat model of Parkinson's disease using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease.Current neuropharmacology · 2019Review
- Striatal Reinnervation Process after Acute Methamphetamine-Induced Dopaminergic Degeneration in Mice.Neurotoxicity research · 2018Article
- Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Conditioning Against the Pathology of Parkinson's disease.Conditioning medicine · 2018Article
- Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.Neurobiology of disease · 2017Article
- The Impact of Short and Long-Term Exercise on the Expression of Arc and AMPARs During Evolution of the 6-Hydroxy-Dopamine Animal Model of Parkinson's Disease.Journal of molecular neuroscience : MN · 2017Article
- MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.Neuroscience bulletin · 2017Article
- Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease.Frontiers in aging neuroscience · 2017Review
- CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration.Neurotoxicity research · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dopaminergic lesions result in the acute loss of striatal dopamine content, the loss of tyrosine hydroxylase-immunoreactive fibers, upregulation of preproenkephalin mRNA expression, and compensatory changes in the synthesis and metabolism of dopamine. Despite the severe loss of fine tyrosine hydroxylase-immunoreactive fibers, larger fibers persist. We found that some tyrosine hydroxylase fiber types increase their branching and become thicker after partial lesion. To determine whether the remaining tyrosine hydroxylase fibers were degenerative or part of a compensatory response, we morphologically characterized striatal tyrosine hydroxylase fibers and compared them to silver-stained degenerative structures. Branched and large tyrosine hydroxylase fiber types were nondegenerative. Furthermore, normal preproenkephalin mRNA expression was maintained despite severe overall loss of tyrosine hydroxylase fibers in striatal regions with abundant branching, whereas preproenkephalin mRNA expression increased in severely depleted regions that lacked branched fibers, indicating that branching or sprouting was involved in the compensation for dopamine depletion and the maintenance of normal preproenkephalin expression. In support of compensatory sprouting by tyrosine hydroxylase fibers, mRNA for growth associated protein-43 was upregulated in dopaminergic midbrain cells. We conclude that an important compensatory response to partial dopaminergic depletion is the formation of new branches or sprouting.
Indexed as
Identifiers
10864967PMC6772281W1651896244What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.