ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 147 citations in OpenAlex.
- The Slit-Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates.Open biology · 2025Review
- Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration.Stem cells (Dayton, Ohio) · 2023Article
- Direct electrical stimulation impacts on neuromuscular junction morphology on both stimulated and unstimulated contralateral soleus.Journal of cachexia, sarcopenia and muscle · 2023Article
- Slit-Robo expression in the leech nervous system: insights into eyespot evolution.Cell & bioscience · 2023Article
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- Zebrafish Slit2 and Slit3 Act Together to Regulate Retinal Axon Crossing at the Midline.Journal of developmental biology · 2022Article
- Proteomic analysis of s-acylated proteins in human retinal pigment epithelial cells and the role of palmitoylation of Niemann-Pick type C1 protein in cholesterol transport.Frontiers in aging neuroscience · 2022Article
- Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.Investigative ophthalmology & visual science · 2019Article
- Assembly and repair of eye-to-brain connections.Current opinion in neurobiology · 2018Review
- Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- F-spondin Is Essential for Maintaining Circadian Rhythms.Frontiers in neural circuits · 2018Article
- Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model.Journal of cardiovascular pharmacology · 2016Article
- Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.eLife · 2015Article
- Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.Neuron · 2015Article
- Birthdate and outgrowth timing predict cellular mechanisms of axon target matching in the developing visual pathway.Cell reports · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate.Developmental neuroscience · 2014Article
- microRNAs in axon guidance.Frontiers in cellular neuroscience · 2014Review
- Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway.The Journal of comparative neurology · 2013Article
- Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos.BMC neuroscience · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We have analyzed the role of the Slit family of repellent axon guidance molecules in the patterning of the axonal projections of retinal ganglion cells (RGCs) within the embryonic rat diencephalon and whether the slits can account for a repellent activity for retinal axons released by hypothalamus and epithalamus. At the time RGC axons extend over the diencephalon, slit1 and slit2 are expressed in hypothalamus and epithalamus but not in the lateral part of dorsal thalamus, a retinal target. slit3 expression is low or undetectable. The Slit receptors robo2, and to a limited extent robo1, are expressed in the RGC layer, as are slit1 and slit2. In collagen gels, axon outgrowth from rat retinal explants is biased away from slit2-transfected 293T cells, and the number and length of axons are decreased on the explant side facing the cells. In addition, in the presence of Slit2, overall axon outgrowth is decreased, and bundles of retinal axons are more tightly fasciculated. This action of Slit2 as a growth inhibitor of retinal axons and the expression patterns of slit1 and slit2 correlate with the fasciculation and innervation patterns of RGC axons within the diencephalon and implicate the Slits as components of the axon repellent activity associated with the hypothalamus and epithalamus. Our findings suggest that in vivo the Slits control RGC axon pathfinding and targeting within the diencephalon by regulating their fasciculation, preventing them or their branches from invading nontarget tissues, and steering them toward their most distal target, the superior colliculus.
Indexed as
Identifiers
10864956PMC6772277W1934664389What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.