ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Intracellular Ca2+ dynamics during spontaneous and evoked activity of leech heart interneurons: low-threshold Ca currents and graded synaptic transmission.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- The T-type calcium channelosome.Pflugers Archiv : European journal of physiology · 2024Review
- Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach.Pharmacology research & perspectives · 2021Article
- Conserved biophysical features of the CaThe Journal of biological chemistry · 2020Article
- Article
- T-type channel-mediated neurotransmitter release.Pflugers Archiv : European journal of physiology · 2014Review
- How do T-type calcium channels control low-threshold exocytosis?Communicative & integrative biology · 2012Article
- A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis.The Journal of biological chemistry · 2012Article
- Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Invertebrate central pattern generator circuits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- A role for compromise: synaptic inhibition and electrical coupling interact to control phasing in the leech heartbeat CpG.Frontiers in behavioral neuroscience · 2010Article
- Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.Journal of neurophysiology · 2009Article
- Ca(2+) signaling by T-type Ca(2+) channels in neurons.Pflugers Archiv : European journal of physiology · 2009Review
- Calcium current diversity in physiologically different local interneuron types of the antennal lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- T-type channels-secretion coupling: evidence for a fast low-threshold exocytosis.Pflugers Archiv : European journal of physiology · 2006Review
- Creation and reduction of a morphologically detailed model of a leech heart interneuron.Journal of neurophysiology · 2006Article
- Mechanisms of postinhibitory rebound and its modulation by serotonin in excitatory swim motor neurons of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- Modulation of spike-mediated synaptic transmission by presynaptic background Ca2+ in leech heart interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Natural patterns of neural activity: how physiological mechanisms are orchestrated to cope with real life.Molecular neurobiology · 2003Review
- Transfer of visual motion information via graded synapses operates linearly in the natural activity range.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Odor-evoked calcium signals in dendrites of rat mitral cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In oscillatory neuronal networks that pace rhythmic behavior, Ca(2+) entry through voltage-gated Ca channels often supports bursting activity and mediates graded transmitter release. We monitored simultaneously membrane potential and/or ionic currents and changes of Ca fluorescence (using the fluorescence indicator Ca Orange) in spontaneously active and experimentally manipulated oscillator heart interneurons in the leech. We show that changes in Ca fluorescence in these interneurons during spontaneous bursting and evoked activity reflect the slow wave of that activity and that these changes in Ca fluorescence are mediated by Ca(2+) entry primarily through low-threshold Ca channels. Spatial and temporal maps of changes in Ca fluorescence indicate that these channels are widely distributed over the neuritic tree of these neurons. We establish a correlation between the amount of transmitter released, as estimated by the integral of the postsynaptic current, and the change in Ca fluorescence. In experiments in which we were able to record presynaptic low-threshold Ca currents, associated IPSCs, and presynaptic changes in Ca fluorescence from fine neuritic branches of heart interneurons near their region of synaptic contact with their contralateral partner, there was a close association between the rise in Ca fluorescence and the rise of the postsynaptic conductance. The changes in Ca fluorescence that we record at the end of fine neuritic branches appear to reflect changes in [Ca(2+)](i) that mediate graded synaptic release in leech heart interneurons. These results indicate that widely distributed low-threshold Ca currents play an important role in generating rhythmic activity and in mediating graded transmitter release.
Indexed as
Identifiers
10864951PMC6772298W1675781162What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.