ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Active zones on motor nerve terminals contain alpha 3beta 1 integrin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.Nature communications · 2021Article
- Multiple roles of integrin-α3 at the neuromuscular junction.Journal of cell science · 2017Article
- The role of laminins in the organization and function of neuromuscular junctions.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- SPARC triggers a cell-autonomous program of synapse elimination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Interactions between ICAM-5 and β1 integrins regulate neuronal synapse formation.Journal of cell science · 2013Article
- Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.Cell reports · 2012Article
- Article
- Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction.Developmental neurobiology · 2011Review
- Presynaptic calcium channels and α3-integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components.Journal of neurochemistry · 2010Article
- Integrin alpha5beta1 function is regulated by XGIPC/kermit2 mediated endocytosis during Xenopus laevis gastrulation.PloS one · 2010Article
- Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis.Developmental biology · 2008Article
- Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.Molecular biology of the cell · 2004Article
- Hypertonicity-induced transmitter release at Drosophila neuromuscular junctions is partly mediated by integrins and cAMP/protein kinase A.The Journal of physiology · 2002Article
- Integrins: the missing link.The Journal of physiology · 2001Article
- Integrin-mediated regulation of synaptic morphology, transmission, and plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Active zones are the sites along nerve terminals where synaptic vesicles dock and undergo calcium-dependent exocytosis during synaptic transmission. Here we show, by immunofluorescent staining with antibodies generated against Xenopus laevis integrins, that alpha3beta1 integrin is concentrated at the active zones of Xenopus motor nerve terminals. Because integrins can link extracellular matrix molecules to cytoskeletal elements and participate in the formation of signaling complexes, the localization of integrin at active zones suggests that it may play a role in the adhesion of the nerve terminals to the synaptic basal lamina, in the formation and maintenance of active zones, and in some of the events associated with calcium-dependent exocytosis of neurotransmitter. Our findings also indicate that the integrin composition of the terminal Schwann cells differs from that of the motor nerve terminals, and this may account at least in part for differences in their adhesiveness to the synaptic basal lamina.
Indexed as
Identifiers
10864949PMC6772282W1527422951What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.