ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Long-term specification of AMPA receptor properties after synapse formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 82 citations in OpenAlex.
- Prolonged visual experience accelerates developmental synaptic downscaling via epigenetic regulation and Rab5c mediated AMPA receptor trafficking.Communications biology · 2026Article
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- Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons.eLife · 2021Article
- Reducing Auditory Nerve Excitability by Acute Antagonism of CaFrontiers in synaptic neuroscience · 2021Article
- Role of GluA3 AMPA Receptor Subunits in the Presynaptic and Postsynaptic Maturation of Synaptic Transmission and Plasticity of Endbulb-Bushy Cell Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset.Frontiers in cellular neuroscience · 2019Article
- Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors.Frontiers in molecular neuroscience · 2018Article
- Factors Influencing Short-term Synaptic Plasticity in the Avian Cochlear Nucleus Magnocellularis.Journal of experimental neuroscience · 2015Article
- Redefining the classification of AMPA-selective ionotropic glutamate receptors.The Journal of physiology · 2012Review
- Ca(2+) permeable AMPA receptors switch allegiances: mechanisms and consequences.The Journal of physiology · 2012Review
- Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?Frontiers in molecular neuroscience · 2012Article
- RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Development of glutamatergic synaptic transmission in binaural auditory neurons.Journal of neurophysiology · 2010Article
- Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- AMPA receptors associated with zebrafish Mauthner cells switch subunits during development.The Journal of physiology · 2007Article
- Development and elimination of endbulb synapses in the chick cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Temporal coding by cochlear nucleus bushy cells in DBA/2J mice with early onset hearing loss.Journal of the Association for Research in Otolaryngology : JARO · 2006Article
- Synaptic transmission at the cochlear nucleus endbulb synapse during age-related hearing loss in mice.Journal of neurophysiology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
AMPA receptors expressed at auditory nerve synapses in the mammalian and avian cochlear nuclei display exceptionally rapid channel gating, an adaptation well suited for acoustic processing. We examined whether cellular interactions during development might determine the subunit composition of these receptors. After synapse formation in the avian nucleus magnocellularis (nMag) in vivo, the rate of receptor desensitization increased threefold, sensitivity to channel block by polyamines increased, and sensitivity to cyclothiazide, an inhibitor of desensitization, increased, indicating a reduction in glutamate receptor subunit 2 and of flip splice variants. This phenotypic switch was prevented, but not reversed, by isolating nMag neurons in a cell-culture environment. We propose that the switch in receptor kinetics is an outcome of cellular interactions during a critical period that result in the long-term determination of receptor phenotype.
Indexed as
Identifiers
10864943PMC6772288W1815650112What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.