ArticleJournal of virology2000
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 149 citations in OpenAlex.
- Article
- Lipidomics reveals the significance and mechanism of the cellular ceramide metabolism for rotavirus replication.Journal of virology · 2024Article
- Article
- Mycotoxin Fumonisin BToxins · 2021Article
- Ceramide and Related Molecules in Viral Infections.International journal of molecular sciences · 2021Review
- Acid-Sphingomyelinase Triggered Fluorescently Labeled Sphingomyelin Containing Liposomes in Tumor Diagnosis after Radiation-Induced Stress.International journal of molecular sciences · 2021Article
- Production of Noncapped Genomic RNAs Is Critical to Sindbis Virus Disease and Pathogenicity.mBio · 2020Article
- Sindbis viral structural protein cytotoxicity on human neuroblastoma cells.Pediatric surgery international · 2020Article
- Tick-Borne Flavivirus Inhibits Sphingomyelinase (Frontiers in cellular and infection microbiology · 2020Article
- Article
- Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome-mediated parasite invasion and plasma membrane repair.Cellular microbiology · 2019Review
- Glucosylceramidase Maintains Influenza Virus Infection by Regulating Endocytosis.Journal of virology · 2019Article
- Influenza virus infection modulates the death receptor pathway during early stages of infection in human bronchial epithelial cells.Physiological genomics · 2018Article
- Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes.PLoS pathogens · 2018Article
- Oncolytic viral therapy for neuroblastoma cells with Sindbis virus AR339 strain.Pediatric surgery international · 2015Article
- Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.Emerging microbes & infections · 2015Article
- Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.Virology · 2015Article
- Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis.Cell death & disease · 2015Article
- Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons.Frontiers in physiology · 2014Review
- Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells.Interdisciplinary perspectives on infectious diseases · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sindbis virus (SV) causes acute encephalomyelitis by infecting and inducing the death of neurons. Induction of apoptosis occurs during virus entry and involves acid-induced conformational changes in the viral surface glycoproteins and sphingomyelin (SM)-dependent fusion of the virus envelope with the endosomal membrane. We have studied neuroblastoma cells to determine how this entry process triggers cell death. Acidic sphingomyelinase was activated during entry followed by activation of neutral sphingomyelinase, SM degradation, and a sustained increase in ceramide. Ceramide-induced apoptosis and SV-induced apoptosis could be inhibited by treatment with Z-VAD-fmk, a caspase inhibitor, and by overexpression of Bcl-2, an antiapoptotic cellular protein. Acid ceramidase, expressed in a recombinant SV, decreased intracellular ceramide and protected cells from apoptosis. The data suggest that acid-induced SM-dependent virus fusion initiates the apoptotic cascade by inducing SM degradation and ceramide release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.